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Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson’s Disease

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cris.virtualsource.author-orcid4dde7a12-8c22-4e89-9d57-7c74b050ccc5
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dc.abstract.enRich in polyphenols, cranberry juice (CJ) with high antioxidant activity is believed to contribute to various health benefits. However, our knowledge of the neuroprotective potential of cranberries is limited. Previously, we have demonstrated that CJ treatment controls oxidative stress in several organs, with the most evident effect in the brain. In this study, we examined the capability of CJ for protection against Parkinson’s disease (PD) in a rotenone (ROT) rat model. Wistar rats were administered with CJ in a dose of 500 mg/kg b.w./day (i.g.) and subcutaneously injected with ROT (1.3 mg/kg b.w./day). The experiment lasted 45 days, including 10 days pre-treatment with CJ and 35 days combined treatment with CJ and ROT. We quantified the expression of α-synuclein and apoptosis markers in the midbrain, performed microscopic examination, and assessed postural instability to evaluate the CJ neuroprotective effect. Our results indicate that the juice treatment provided neuroprotection, as evidenced by declined α-synuclein accumulation, Bax and cleaved/active caspase-9 expression, and normalized cytochrome c level that was accompanied by the enhancement of neuronal activity survival and improved postural instability. Importantly, we also found that long-term administration of CJ alone in a relatively high dose may exert a deleterious effect on cell survival in the midbrain.
dc.affiliationWydział Rolnictwa, Ogrodnictwa i Biotechnologii
dc.affiliation.instituteKatedra Biochemii i Biotechnologii
dc.contributor.authorWitucki, Łukasz
dc.contributor.authorKurpik, Monika
dc.contributor.authorJakubowski, Hieronim
dc.contributor.authorSzulc, Michał
dc.contributor.authorŁukasz Mikołajczak, Przemysław
dc.contributor.authorJodynis-Liebert, Jadwiga
dc.contributor.authorKujawska, Małgorzata
dc.date.access2025-11-20
dc.date.accessioned2025-11-20T09:39:44Z
dc.date.available2025-11-20T09:39:44Z
dc.date.copyright2022-05-11
dc.date.issued2022
dc.description.abstract<jats:p>Rich in polyphenols, cranberry juice (CJ) with high antioxidant activity is believed to contribute to various health benefits. However, our knowledge of the neuroprotective potential of cranberries is limited. Previously, we have demonstrated that CJ treatment controls oxidative stress in several organs, with the most evident effect in the brain. In this study, we examined the capability of CJ for protection against Parkinson’s disease (PD) in a rotenone (ROT) rat model. Wistar rats were administered with CJ in a dose of 500 mg/kg b.w./day (i.g.) and subcutaneously injected with ROT (1.3 mg/kg b.w./day). The experiment lasted 45 days, including 10 days pre-treatment with CJ and 35 days combined treatment with CJ and ROT. We quantified the expression of α-synuclein and apoptosis markers in the midbrain, performed microscopic examination, and assessed postural instability to evaluate the CJ neuroprotective effect. Our results indicate that the juice treatment provided neuroprotection, as evidenced by declined α-synuclein accumulation, Bax and cleaved/active caspase-9 expression, and normalized cytochrome c level that was accompanied by the enhancement of neuronal activity survival and improved postural instability. Importantly, we also found that long-term administration of CJ alone in a relatively high dose may exert a deleterious effect on cell survival in the midbrain.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_act
dc.description.financecost6708,62
dc.description.if5,9
dc.description.number10
dc.description.points140
dc.description.versionfinal_published
dc.description.volume14
dc.identifier.doi10.3390/ijms26020746
dc.identifier.issn2072-6643
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6009
dc.identifier.weblinkhttps://www.mdpi.com/2072-6643/14/10/2014
dc.languageen
dc.pbn.affiliationbiological sciences
dc.relation.ispartofNutrients
dc.relation.pagesart. 2014
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enParkinson’s disease
dc.subject.enα-synuclein
dc.subject.enapoptosis
dc.subject.enpostural instability
dc.titleNeuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson’s Disease
dc.title.volumeSpecial Issue Polyphenols and Polyphenol-Rich Foods in Neurodegenerative Disorders
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue10
oaire.citation.volume14