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Evaluation of the cariogenicity of prebiotic (1-3) -α-D-glucooligosaccharides

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dc.abstract.enOne of the important features of prebiotics is their beneficial effect on the health of the host, which consists of the inhibition of the growth of harmful bacteria, including strains causing caries. The aim of the present study was to evaluate the cariogenic potential of a hydrolyzate of (1→3)-α-D-glucan (GOS) isolated from fruiting bodies of Laetiporus sulphureus, consisting of (1→3)-α-D-glucooligosaccharides (85.6%) and glucose (14.4%). The study was conducted in cultures of cariogenic bacteria belonging to the genus Streptococcus (S. mutans CAPM 6067, S. sobrinus DSMZ 20381, S. sobrinus/downei CCUG 21020, and S. sanguis ATCC 10556). The investigation of the cariogenicity of GOS included an examination of the influence of the preparation on the growth of the above-mentioned bacteria, their ability to synthesize mutan, and the formation of a sucrose-dependent biofilm. GOS significantly inhibited the growth of the investigated streptococci, and the observed beneficial effect was stronger than the changes induced by a commercial prebiotic preparation containing a mixture of fructooligosaccharides (FOS). Furthermore, GOS inhibited the mutan synthesis by the above-mentioned bacteria but did not exert an impact on the formation of artificial dental plaque. In conclusion, the studies conducted showed low cariogenicity of GOS and confirmed the safety of its use as a dietary supplement
dc.affiliationWydział Rolnictwa, Ogrodnictwa i Biotechnologii
dc.affiliation.instituteKatedra Warzywnictwa
dc.contributor.authorAdamczyk, Paulina
dc.contributor.authorLemieszek, Marta
dc.contributor.authorOzimek, Ewa
dc.contributor.authorPleszczyńska, Małgorzata
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorSiwulski, Marek
dc.contributor.authorSroka-Bartnicka, Anna
dc.contributor.authorWiater, Adrian
dc.date.access2025-12-05
dc.date.accessioned2025-12-05T08:48:04Z
dc.date.available2025-12-05T08:48:04Z
dc.date.copyright2022-12-28
dc.date.issued2022
dc.description.abstract<jats:p>One of the important features of prebiotics is their beneficial effect on the health of the host, which consists in the inhibition of the growth of harmful bacteria, including strains causing caries. The aim of the present study was to evaluate the cariogenic potential of a hydrolyzate of (1→3)-α-D-glucan (GOS) isolated from fruiting bodies of Laetiporus sulphureus, consisting of (1→3)-α-D-glucooligosaccharides (85.6%) and glucose (14.4%). The study was conducted in cultures of cariogenic bacteria belonging to the genus Streptococcus (S. mutans CAPM 6067, S. sobrinus DSMZ 20381, S. sobrinus/downei CCUG 21020, and S. sanguis ATCC 10556). The investigation of the cariogenicity of GOS included examination of the influence of the preparation on the growth of the above mentioned bacteria, their ability to synthesize mutan, and the formation of a sucrose-dependent biofilm. GOS significantly inhibited the growth of the investigated streptococci, and the observed beneficial effect was stronger than the changes induced by a commercial prebiotic preparation containing a mixture of fructooligosaccharides (FOS). Furthermore, GOS inhibited the mutan synthesis by the above mentioned bacteria but did not exert an impact on the formation of artificial dental plaque. In conclusion, the studies conducted showed low cariogenicity of GOS and confirmed the safety of its use as a dietary supplement.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if0,4
dc.description.number5
dc.description.points100
dc.description.versionfinal_published
dc.description.volume79
dc.identifier.doi10.32383/appdr/158785
dc.identifier.eissn2353-5288
dc.identifier.issn0001-6837
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6226
dc.identifier.weblinkhttps://www.ptfarm.pl/download/?file=File%2FActa_Poloniae%2F2022%2F5%2F635.pdf
dc.languageen
dc.relation.ispartofActa Poloniae Pharmaceutica - Drug Research
dc.relation.pages635-642
dc.rightsCC-BY-NC
dc.sciencecloudnosend
dc.share.typeOTHER
dc.subject.enStreptococcus mutans
dc.subject.endental caries
dc.subject.enprebiotics
dc.subject.en(1→3)-α-D-glucooligosaccharides
dc.subject.enprebiotic characteristics
dc.titleEvaluation of the cariogenicity of prebiotic (1-3) -α-D-glucooligosaccharides
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue5
oaire.citation.volume79