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Calcium carbonate-enriched pumpkin affects calcium status in ovariectomized rats

cris.lastimport.scopus2025-10-23T06:59:53Z
cris.virtual.author-orcid0000-0002-0744-9033
cris.virtual.author-orcid0000-0003-0715-0223
cris.virtual.author-orcid0000-0002-0937-8427
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cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid968d3cb8-3b2b-46fe-a17f-373169a0738c
cris.virtualsource.author-orcid0c22ceb5-e5c6-4f5d-a0fd-8ec91a16efa9
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cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enCalcium carbonate (CaCO3)-enriched pumpkin may serve as a good source of calcium for patients diagnosed with osteoporosis. In this study, we aimed to determine the effect of CaCO3-enriched pumpkin on Ca status in ovariectomized rats. The study included 40 female Wistar rats divided into five groups (n = 8). One group was fed with a standard diet (control group), while the other four groups were ovariectomized and received a standard diet (control ovariectomized group), or a diet containing CaCO3-enriched pumpkin, alendronate, or both. The nutritional intervention lasted 12 weeks, and then the rats were euthanized. Tissue and blood samples were collected and assessed for the levels of total Ca, estradiol, parathyroid hormone, and procollagen type I N propeptide. In addition, a histological analysis was performed on femurs. The results of the study suggest that CaCO3-enriched pumpkin can increase Ca content in femurs and improve bone recovery in ovariectomized rats. Furthermore, enriched pumpkin contributes to Ca accumulation in the kidneys, and this effect is more pronounced in combination with alendronate.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Technologii Gastronomicznej i Żywności Funkcjonalnej
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorWawrzyniak, Natalia
dc.contributor.authorGramza-Michałowska, Anna
dc.contributor.authorKurzawa, Paweł
dc.contributor.authorKołodziejski, Paweł Antoni
dc.contributor.authorSuliburska, Joanna
dc.date.access2023-02-10
dc.date.accessioned2025-08-26T12:06:33Z
dc.date.available2025-08-26T12:06:33Z
dc.date.copyright2023-02-10
dc.date.issued2023
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>Calcium carbonate (CaCO<jats:sub>3</jats:sub>)-enriched pumpkin may serve as a good source of calcium for patients diagnosed with osteoporosis. In this study, we aimed to determine the effect of CaCO<jats:sub>3</jats:sub>-enriched pumpkin on Ca status in ovariectomized rats. The study included 40 female Wistar rats divided into five groups (n = 8). One group was fed with a standard diet (control group), while the other four groups were ovariectomized and received a standard diet (control ovariectomized group), or a diet containing CaCO<jats:sub>3</jats:sub>-enriched pumpkin, alendronate, or both. The nutritional intervention lasted 12 weeks, and then the rats were euthanized. Tissue and blood samples were collected and assessed for the levels of total Ca, estradiol, parathyroid hormone, and procollagen type I N propeptide. In addition, a histological analysis was performed on femurs. The results of the study suggest that CaCO<jats:sub>3</jats:sub>-enriched pumpkin can increase Ca content in femurs and improve bone recovery in ovariectomized rats. Furthermore, enriched pumpkin contributes to Ca accumulation in the kidneys, and this effect is more pronounced in combination with alendronate.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if2,6
dc.description.number4
dc.description.points70
dc.description.versionfinal_published
dc.description.volume60
dc.identifier.doi10.1007/s13197-023-05686-3
dc.identifier.eissn0975-8402
dc.identifier.issn0022-1155
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4386
dc.languageen
dc.pbn.affiliationfood and nutrition technology
dc.relation.ispartofJournal of Food Science and Technology
dc.relation.pages1402–1413
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOTHER
dc.subject.encalcium
dc.subject.enenriched pumpkin
dc.subject.enosteoporosis
dc.subject.enovariectomy
dc.subject.enrat
dc.titleCalcium carbonate-enriched pumpkin affects calcium status in ovariectomized rats
dc.typeJournalArticle
dspace.entity.typePublication