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A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake on Inflammatory Markers in Postmenopausal Women

cris.virtual.author-orcid0000-0002-2268-9326
cris.virtual.author-orcid0000-0003-1996-5198
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cris.virtual.author-orcid0000-0002-3265-547X
cris.virtual.author-orcid0000-0001-6419-3401
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cris.virtualsource.author-orcid190a1224-971b-4b6e-a791-aa08ba93ca89
cris.virtualsource.author-orcid1ccb8edd-cf11-49a4-bd1c-af5fd753fdc7
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cris.virtualsource.author-orcid091e5383-d189-49f2-92f7-53eca8eeb034
cris.virtualsource.author-orcidbd5b6ffb-49a4-4a23-815b-fbdb6b37d171
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dc.abstract.enBackground Elevated concentrations of serum inflammatory cytokines, specifically TNF-α and IL-6, as well as C-reactive protein (CRP), are commonly observed after menopause. Objectives Because soy isoflavones may have some anti-inflammatory potential, the aim of the present systematic review and meta-analysis of randomized controlled trials (RCTs) was to explore whether soy intake affects serum markers of inflammation in postmenopausal women. Methods PubMed, Web of Science, and the Cochrane Library were systematically searched up to August 2020. All RCTs that met the following criteria were included: 1) studies of the effects of soy intake on inflammatory markers; 2) any date of publication; 3) conducted on postmenopausal women; 4) with sufficient quantitative data for meta-analysis. Effect sizes were expressed as weighted mean differences (WMDs) and 95% CIs. A total of 24 RCTs assessing the effects of soy intake on serum concentrations of CRP, TNF-α, and IL-6 were included in the analysis. A random-effects model was used to determine the overall effect. Results Soy supplementation significantly reduced CRP by 0.11 mg/L in postmenopausal women (95% CI: −0.22, −0.004 mg/L; P = 0.0414), but did not affect IL-6 or TNF-α. Significant reductions in CRP concentration occurred when natural soy products were given (WMD: −0.23 mg/L; 95% CI: −0.29, −0.17 mg/L; P < 0.001). This is equivalent to a ∼9% reduction in CRP concentration from baseline. Conclusions Although our meta-analysis found evidence that soy products significantly reduce CRP concentrations in postmenopausal women, the mechanisms by which soy foods and their constituents affect inflammatory biomarkers still need to be clarified.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorBajerska, Joanna
dc.contributor.authorŁagowska, Karolina
dc.contributor.authorMori, Mari
dc.contributor.authorReguła, Julita
dc.contributor.authorSkoczek-Rubińska, Aleksandra
dc.contributor.authorToda, Toshiya
dc.contributor.authorMizuno, Naho
dc.contributor.authorYamori, Yukio
dc.date.access2026-03-02
dc.date.accessioned2026-03-17T12:30:08Z
dc.date.available2026-03-17T12:30:08Z
dc.date.copyright2021-10-12
dc.date.issued2022
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,3
dc.description.number1
dc.description.points140
dc.description.versionfinal_published
dc.description.volume152
dc.identifier.doi10.1093/jn/nxab325
dc.identifier.eissn1541-6100
dc.identifier.issn0022-3166
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7791
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S0022316622004977
dc.languageen
dc.relation.ispartofJournal of Nutrition
dc.relation.pages5-15
dc.rightsOther
dc.sciencecloudnosend
dc.share.typeOTHER
dc.subject.ensoyisoflavones
dc.subject.enpostmenopausal women
dc.subject.eninflammation
dc.subject.enC-reactive protein
dc.subject.enmeta-analysis
dc.titleA Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake on Inflammatory Markers in Postmenopausal Women
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume152