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Bioactive Compounds, Ruminal Fermentation, and Anthelmintic Activity of Specialty Coffee and Spent Coffee Grounds In Vitro

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dc.abstract.enWe quantified the bioactive compounds of Ethiopian coffee (ETH), spent coffee grounds SCGs from ETH (SCG-ETH), and mixed SCGs (SCG-MIX) prepared by filtration methods and investigated the effect of SCG-ETH on ruminal fermentation as well as the anthelmintic activity of ETH. Three substrates, meadow hay (MH)-barley grain (MH-BG), MH-SCG-ETH, and BG-SCG-ETH (1:1 w/w), were fermented using an in vitro gas production technique. The bioactive compounds were quantitatively analyzed using ultra-high-resolution mass spectrometry. We performed an in vitro larval development test to determine the anthelmintic effect of an aqueous extract of ETH against the gastrointestinal nematode (GIN) Haemonchus contortus. The total content of bioactive compounds was highest in SCG-ETH, followed by SCG-MIX and ETH (35.2, 31.2, and 20.9 mg/g dry matter, respectively). Total gas and methane production (p < 0.001) were decreased by both MH-SCG-ETH and BG-SCG-ETH. The in vitro digestibility of dry matter was higher for MH-SCG-ETH and BG-SCG-ETH than for MH-BG. The aqueous ETH extract exhibited a strong larvicidal effect, with a mean lethal dose of 13.2 mg/mL for 50% mortality and 31.9 mg/L for 99% mortality. SCG substrates have the potential to modulate ruminal fermentation and serve as a source of anthelmintic bioactive compounds against GINs in ruminants.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Żywienia Zwierząt
dc.contributor.authorLeško, Matej
dc.contributor.authorPetrič, Daniel
dc.contributor.authorVárady, Matúš
dc.contributor.authorSidoruk, Pola
dc.contributor.authorMikuła, Robert
dc.contributor.authorŚlusarczyk, Sylwester
dc.contributor.authorHodurek, Paweł Edward
dc.contributor.authorKomáromyová, Michaela
dc.contributor.authorBabják, Michal
dc.contributor.authorVárady, Marián
dc.contributor.authorPatra, Amlan Kumar
dc.contributor.authorCieślak, Adam
dc.contributor.authorVáradyová, Zora
dc.date.access2025-10-06
dc.date.accessioned2025-10-06T05:50:07Z
dc.date.available2025-10-06T05:50:07Z
dc.date.copyright2025-07-14
dc.date.issued2025
dc.description.abstract<jats:p>We quantified the bioactive compounds of Ethiopian coffee (ETH), spent coffee grounds SCGs from ETH (SCG-ETH), and mixed SCGs (SCG-MIX) prepared by filtration methods and investigated the effect of SCG-ETH on ruminal fermentation as well as the anthelmintic activity of ETH. Three substrates, meadow hay (MH)-barley grain (MH-BG), MH-SCG-ETH, and BG-SCG-ETH (1:1 w/w), were fermented using an in vitro gas production technique. The bioactive compounds were quantitatively analyzed using ultra-high-resolution mass spectrometry. We performed an in vitro larval development test to determine the anthelmintic effect of an aqueous extract of ETH against the gastrointestinal nematode (GIN) Haemonchus contortus. The total content of bioactive compounds was highest in SCG-ETH, followed by SCG-MIX and ETH (35.2, 31.2, and 20.9 mg/g dry matter, respectively). Total gas and methane production (p &lt; 0.001) were decreased by both MH-SCG-ETH and BG-SCG-ETH. The in vitro digestibility of dry matter was higher for MH-SCG-ETH and BG-SCG-ETH than for MH-BG. The aqueous ETH extract exhibited a strong larvicidal effect, with a mean lethal dose of 13.2 mg/mL for 50% mortality and 31.9 mg/L for 99% mortality. SCG substrates have the potential to modulate ruminal fermentation and serve as a source of anthelmintic bioactive compounds against GINs in ruminants.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,6
dc.description.number14
dc.description.points100
dc.description.versionfinal_published
dc.description.volume15
dc.identifier.doi10.3390/agriculture15141515
dc.identifier.eissn2077-0472
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5186
dc.identifier.weblinkhttps://www.mdpi.com/2077-0472/15/14/1515
dc.languageen
dc.pbn.affiliationanimal science and fisheries
dc.relation.ispartofAgriculture (Switzerland)
dc.relation.pagesart. 1515
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enfiltered specialty coffees
dc.subject.encoffee grounds
dc.subject.enanthelmintic compounds
dc.subject.enmethane emissions
dc.subject.enruminal fermentation
dc.subject.enciliate protozoan
dc.subject.enbioactive substances
dc.titleBioactive Compounds, Ruminal Fermentation, and Anthelmintic Activity of Specialty Coffee and Spent Coffee Grounds In Vitro
dc.title.volumeSpecial Issue Utilizing Novel and Alternative Sources of Feed for Animal Production
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue14
oaire.citation.volume15