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Lactiplantibacillus plantarum, Duodenal Hydroxyphenyllactic Acid and Iron: Insights from a Rat Model of a High-Fat Iron-Deficient Diet

cris.virtual.author-orcid0000-0002-4173-5965
cris.virtual.author-orcid0000-0002-5418-5632
cris.virtual.author-orcid0000-0001-8417-2245
cris.virtual.author-orcid0000-0002-0937-8427
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcidc8f75a2c-3403-4f93-aa73-6cf0ae8b543d
cris.virtualsource.author-orcidccd52a90-8355-4384-b6ea-c94578ebf2ce
cris.virtualsource.author-orcidedf63522-bb89-4788-a8d3-9c3f3858875b
cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enBackground: Lactiplantibacillus plantarum synthesizes in vitro hydroxyphenyllactic acid (HPLA)—an iron-reducing agent supposed to facilitate duodenal Fe absorption. So far, no such in vivo HPLA production has been established. This study aimed to investigate the ability of Lactiplantibacillus plantarum to produce HPLA in the duodenum in rats on a high-fat iron-deficient diet. Methods: Rats were fed a high fat (HF) diet; HF, Fe-deficient diet (HFDEF); or control (C) diet for 8 weeks. Over the next 8 weeks, animals in the C and HF groups continued on their respective diets, while animals in the HFDEF group were divided into six subgroups and received combinations of an HF, Fe-deficient diet with Lactiplantibacillus plantarum (Lp), Latilactobacillus curvatus (Lc), and Fe supplementation (HFDEF, HFDEFFe, HFDEFLp, HFDEFLc, HFDEFFeLp, and HFDEFFeLc). Duodenal and faecal samples were collected. Results: No significant differences were observed in HPLA content in the duodenum and faeces, nor in Fe chelating abilities in faeces, between study groups at the completion of the study. Fe content in faeces was higher in the HFDEFFe group than in the C, HF, HFDEF, HFDEFLp, and HFDEFLc groups. Fe content in faeces was higher in the HFDEFFeLp and HFDEFFeLc groups than in the HFDEF and HFDEFLc groups. Conclusions: Lactiplantibacillus plantarum, whether alone or with oral Fe, does not influence duodenal and faecal HPLA content, nor does it affect faecal Fe chelating abilities in rats on the HF, Fe-deficient diet.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.contributor.authorSkrypnik, Katarzyna
dc.contributor.authorOlejnik-Schmidt, Agnieszka
dc.contributor.authorSchmidt, Marcin
dc.contributor.authorSelvan, Damla
dc.contributor.authorSuliburska, Joanna
dc.date.access2025-11-03
dc.date.accessioned2025-11-04T06:32:33Z
dc.date.available2025-11-04T06:32:33Z
dc.date.copyright2025-11-01
dc.date.issued2025
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if5,0
dc.description.number21
dc.description.points140
dc.description.versionfinal_published
dc.description.volume17
dc.identifier.doi10.3390/nu17213454
dc.identifier.issn2072-6643
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5698
dc.identifier.weblinkhttps://www.mdpi.com/2072-6643/17/21/3454
dc.languageen
dc.relation.ispartofNutrients
dc.relation.pagesart. 3454
dc.relation.projectBadanie wpływu Lactobacillus plantarum ATCC14917 na gospodarkę żelaza u szczurów na diecie wysokotłuszczowej
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enprobiotics
dc.subject.enduodenum
dc.subject.enhigh-fat diet
dc.subject.eniron deficient diet
dc.subject.enhydroxyphenyllactic acid
dc.subject.enHPLA
dc.titleLactiplantibacillus plantarum, Duodenal Hydroxyphenyllactic Acid and Iron: Insights from a Rat Model of a High-Fat Iron-Deficient Diet
dc.typeJournalArticle
dspace.entity.typePublication