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Extremely Rare Flavonoid Glycosides Identified in the Stems of Ephedra gerardiana by HPLC-MS and Their Antioxidant Activity

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cris.virtual.author-orcid0000-0003-1305-6866
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dc.abstract.enThe plants of the genus Ephedra are mainly known for the contents of alkaloids; however, it has recently been found that they also contain phenolic constituents that show interesting bioactivities, e.g., antioxidative or antimicrobial. From among the Ephedrae herba, the Ephedra gerardiana seems to be relatively poorly researched in terms of flavonoid presence. In this study, on the basis of the results of high-pressure liquid chromatography–mass spectrometry (HPLC-MS) with cone voltage-induced fragmentation analysis, which are discussed in detail, the flavonoid glycosides present in Ephedra gerardiana have been identified. Besides the flavonoids typical of the genus Ephedra, e.g., afzelin, herbacetin 7-O-glucoside, and vicenin-2, compounds that are very rare in nature have been detected as well, namely the p-coumaroyl conjugates of 4′-O-methylafzelin and malonyl flavone C-glycosides. Therefore, Ephedra gerardiana can be regarded as a valuable source of these compounds. Furthermore, the antioxidant activity of the methanol extract indicates that these compounds show potential interesting biological activities.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Biochemii i Analizy Żywności
dc.contributor.authorSzymborska, Karolina
dc.contributor.authorFrański, Rafał
dc.contributor.authorGierczyk, Błażej
dc.contributor.authorBeszterda-Buszczak, Monika
dc.date.access2025-10-09
dc.date.accessioned2025-10-09T10:47:40Z
dc.date.available2025-10-09T10:47:40Z
dc.date.copyright2025-03-27
dc.date.issued2025
dc.description.abstract<jats:p>The plants of the genus Ephedra are mainly known for the contents of alkaloids; however, it has recently been found that they also contain phenolic constituents that show interesting bioactivities, e.g., antioxidative or antimicrobial. From among the Ephedrae herba, the Ephedra gerardiana seems to be relatively poorly researched in terms of flavonoid presence. In this study, on the basis of the results of high-pressure liquid chromatography–mass spectrometry (HPLC-MS) with cone voltage-induced fragmentation analysis, which are discussed in detail, the flavonoid glycosides present in Ephedra gerardiana have been identified. Besides the flavonoids typical of the genus Ephedra, e.g., afzelin, herbacetin 7-O-glucoside, and vicenin-2, compounds that are very rare in nature have been detected as well, namely the p-coumaroyl conjugates of 4′-O-methylafzelin and malonyl flavone C-glycosides. Therefore, Ephedra gerardiana can be regarded as a valuable source of these compounds. Furthermore, the antioxidant activity of the methanol extract indicates that these compounds show potential interesting biological activities.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,9
dc.description.number7
dc.description.points140
dc.description.versionfinal_published
dc.description.volume26
dc.identifier.doi10.3390/ijms26073097
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5340
dc.identifier.weblinkhttps://www.mdpi.com/1422-0067/26/7/3097
dc.languageen
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.pagesart. 3097
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enflavonoid glycosides
dc.subject.enEphedra gerardiana
dc.subject.enmass spectrometry
dc.subject.enliquid chromatography
dc.subject.enfragmentation patterns
dc.subject.enDPPH
dc.titleExtremely Rare Flavonoid Glycosides Identified in the Stems of Ephedra gerardiana by HPLC-MS and Their Antioxidant Activity
dc.title.volumeSpecial Issue Applications of Mass Spectrometry in the Analysis of Bioactive and Plant Organic Compounds
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue7
oaire.citation.volume26