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Impact of dietary salicylates on angiogenic factors and biochemical parameters in a rat model of preeclampsia

cris.virtual.author-orcid0000-0002-0937-8427
cris.virtual.author-orcid0000-0003-4113-1595
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cris.virtual.author-orcid0000-0002-4173-5965
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cris.virtual.author-orcid0000-0003-0715-0223
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cris.virtual.author-orcid0000-0001-7518-579X
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cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
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dc.abstract.enBackground The pathophysiology of preeclampsia involves impaired cytotrophoblastic invasion, placental ischemia, inflammation, and angiogenic imbalance. Prophylactic low-dose aspirin can reduce the risk of preeclampsia and fetal growth restriction in high-risk women. This study evaluated the effect of dietary salicylates on the development of preeclampsia in rats treated with L-NAME (NG-nitro-L-argininemethyl ester). Methodology Pregnant Sprague-Dawley rats were randomly assigned to six groups and treated with dietary salicylates at two dose levels (1 and 10mg/kg diet) or aspirin (doses adjusted to dietary salicylates). Preeclampsia was induced by administering L-NAME in drinking water from gestational days 6–19. Results Neither dietary salicylates nor aspirin, at either dose, affected blood pressure in L-NAME-treated rats. The lower dose of dietary salicylates significantly reduced urinary albumin levels. Both interventions prevented an increase in the sFlt/PLGF ratio and mitigated histopathological placental changes in preeclamptic rats. The higher dose of aspirin reduced placental VEGFR2 protein levels. Conclusion Dietary salicylate supplementation does not provide clear preventive effects against preeclampsia.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliationWydział Leśny i Technologii Drewna
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.affiliation.instituteKatedra Chemii
dc.affiliation.instituteKatedra Fizjologii, Biochemii i Biostruktury Zwierząt
dc.affiliation.instituteKatedra Żywienia Zwierząt
dc.contributor.authorSuliburska, Joanna
dc.contributor.authorCholik, Rafsan Syabani
dc.contributor.authorKaraźniewicz-Łada, Marta
dc.contributor.authorWronka, Dorota
dc.contributor.authorKarlik, Anna
dc.contributor.authorWaśkiewicz, Agnieszka
dc.contributor.authorSkrypnik, Katarzyna
dc.contributor.authorKołodziejski, Paweł
dc.contributor.authorCieślak, Adam
dc.contributor.authorPrzybył, Łukasz
dc.date.access2025-09-30
dc.date.accessioned2025-10-02T07:28:51Z
dc.date.available2025-10-02T07:28:51Z
dc.date.copyright2025-09-29
dc.date.issued2025
dc.description.abstract<jats:sec id="sec001"> <jats:title>Background</jats:title> <jats:p>The pathophysiology of preeclampsia involves impaired cytotrophoblastic invasion, placental ischemia, inflammation, and angiogenic imbalance. Prophylactic low-dose aspirin can reduce the risk of preeclampsia and fetal growth restriction in high-risk women. This study evaluated the effect of dietary salicylates on the development of preeclampsia in rats treated with L-NAME (NG-nitro-L-arginine-methyl ester).</jats:p> </jats:sec> <jats:sec id="sec002"> <jats:title>Methodology</jats:title> <jats:p>Pregnant Sprague-Dawley rats were randomly assigned to six groups and treated with dietary salicylates at two dose levels (1 and 10 mg/kg diet) or aspirin (doses adjusted to dietary salicylates). Preeclampsia was induced by administering L-NAME in drinking water from gestational days 6–19.</jats:p> </jats:sec> <jats:sec id="sec003"> <jats:title>Results</jats:title> <jats:p>Neither dietary salicylates nor aspirin, at either dose, affected blood pressure in L-NAME-treated rats. The lower dose of dietary salicylates significantly reduced urinary albumin levels. Both interventions prevented an increase in the sFlt/PLGF ratio and mitigated histopathological placental changes in preeclamptic rats. The higher dose of aspirin reduced placental VEGFR2 protein levels.</jats:p> </jats:sec> <jats:sec id="sec004"> <jats:title>Conclusion</jats:title> <jats:p>Dietary salicylate supplementation does not provide clear preventive effects against preeclampsia.</jats:p> </jats:sec>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if2,6
dc.description.number9
dc.description.points100
dc.description.versionfinal_published
dc.description.volume20
dc.identifier.doi10.1371/journal.pone.0333543
dc.identifier.issn1932-6203
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5143
dc.identifier.weblinkhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0333543
dc.languageen
dc.relation.ispartofPLoS ONE
dc.relation.pagese0333543
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.titleImpact of dietary salicylates on angiogenic factors and biochemical parameters in a rat model of preeclampsia
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue9
oaire.citation.volume20