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Characteristics of Chitosan Films with the Bioactive Substances—Caffeine and Propolis

cris.virtual.author-orcid0000-0002-1863-5122
cris.virtual.author-orcid0000-0002-0120-2734
cris.virtual.author-orcid0000-0002-6713-8077
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cris.virtual.author-orcid0000-0003-3026-5192
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cris.virtualsource.author-orcid44370511-a743-43d2-9522-1c489f4cabcf
cris.virtualsource.author-orcid5ad889ad-842c-4ab2-9a0e-ea77e6f75f9c
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dc.abstract.enChitosan is a natural and biodegradable polymer with promising potential for biomedical applications. This study concerns the production of chitosan-based materials for future use in the medical industry. Bioactive substances—caffeine and ethanolic propolis extract (EEP)—were incorporated into a chitosan matrix to increase the bioactivity of the obtained films and improve their mechanical properties. Acetic and citric acids were used as solvents in the production of the chitosan-based films. The obtained materials were characterized in terms of their antibacterial and antifungal activities, as well as their mechanical properties, including tensile strength and elongation at break. Moreover, the chemical structures and surface morphologies of the films were assessed. The results showed that the solution consisting of chitosan, citric acid, caffeine, and EEP exhibited an excellent antiradical effect. The activity of this solution (99.13%) was comparable to that of the standard antioxidant Trolox (92.82%). In addition, the film obtained from this solution showed good antibacterial activity, mainly against Escherichia coli and Enterococcus faecalis. The results also revealed that the films produced with citric acid exhibited higher activity levels against pathogenic bacteria than the films obtained with acetic acid. The antimicrobial effect of the chitosan-based films could be further enhanced by adding bioactive additives such as caffeine and propolis extract. The mechanical tests showed that the solvents and additives used affected the mechanical properties of the films obtained. The film produced from chitosan and acetic acid was characterized by the highest tensile strength value (46.95 MPa) while the chitosan-based film with citric acid showed the lowest value (2.28 MPa). The addition of caffeine and propolis to the film based on chitosan with acetic acid decreased its tensile strength while in the case of the chitosan-based film with citric acid, an increase in strength was observed. The obtained results suggested that chitosan films with natural bioactive substances can be a promising alternative to the traditional materials used in the medical industry, for example, as including biodegradable wound dressings or probiotic encapsulation materials.
dc.affiliationWydział Leśny i Technologii Drewna
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Chemii
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.affiliation.instituteKatedra Nauki o Drewnie i Techniki Cieplnej
dc.contributor.authorStefanowska, Karolina
dc.contributor.authorWoźniak, Magdalena
dc.contributor.authorSip, Anna
dc.contributor.authorMrówczyńska, Lucyna
dc.contributor.authorMajka, Jerzy
dc.contributor.authorKozak, Wojciech
dc.contributor.authorDobrucka, Renata
dc.contributor.authorRatajczak, Izabela
dc.date.access2025-08-27
dc.date.accessioned2025-08-27T07:21:43Z
dc.date.available2025-08-27T07:21:43Z
dc.date.copyright2023-07-09
dc.date.issued2023
dc.description.abstract<jats:p>Chitosan is a natural and biodegradable polymer with promising potential for biomedical applications. This study concerns the production of chitosan-based materials for future use in the medical industry. Bioactive substances—caffeine and ethanolic propolis extract (EEP)—were incorporated into a chitosan matrix to increase the bioactivity of the obtained films and improve their mechanical properties. Acetic and citric acids were used as solvents in the production of the chitosan-based films. The obtained materials were characterized in terms of their antibacterial and antifungal activities, as well as their mechanical properties, including tensile strength and elongation at break. Moreover, the chemical structures and surface morphologies of the films were assessed. The results showed that the solution consisting of chitosan, citric acid, caffeine, and EEP exhibited an excellent antiradical effect. The activity of this solution (99.13%) was comparable to that of the standard antioxidant Trolox (92.82%). In addition, the film obtained from this solution showed good antibacterial activity, mainly against Escherichia coli and Enterococcus faecalis. The results also revealed that the films produced with citric acid exhibited higher activity levels against pathogenic bacteria than the films obtained with acetic acid. The antimicrobial effect of the chitosan-based films could be further enhanced by adding bioactive additives such as caffeine and propolis extract. The mechanical tests showed that the solvents and additives used affected the mechanical properties of the films obtained. The film produced from chitosan and acetic acid was characterized by the highest tensile strength value (46.95 MPa) while the chitosan-based film with citric acid showed the lowest value (2.28 MPa). The addition of caffeine and propolis to the film based on chitosan with acetic acid decreased its tensile strength while in the case of the chitosan-based film with citric acid, an increase in strength was observed. The obtained results suggested that chitosan films with natural bioactive substances can be a promising alternative to the traditional materials used in the medical industry, for example, as including biodegradable wound dressings or probiotic encapsulation materials.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if5
dc.description.number7
dc.description.points100
dc.description.versionfinal_published
dc.description.volume14
dc.identifier.doi10.3390/jfb14070358
dc.identifier.issn2079-4983
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4405
dc.identifier.weblinkhttps://www.mdpi.com/2079-4983/14/7/358
dc.languageen
dc.relation.ispartofJournal of Functional Biomaterials
dc.relation.pagesart. 357
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enbiomedical materials
dc.subject.enchitosan
dc.subject.enpropolis
dc.subject.encaffeine
dc.subject.enchitosan films
dc.titleCharacteristics of Chitosan Films with the Bioactive Substances—Caffeine and Propolis
dc.title.volumeSpecial Issue Chitosan Microparticles: Development, Characterization and Biomedical Applications
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue7
oaire.citation.volume14