Rosehip Extract Decreases Reactive Oxygen Species Production and Lipid Accumulation in Hypertrophic 3T3-L1 Adipocytes with the Modulation of Inflammatory State
| cris.virtual.author-orcid | 0000-0001-7706-4035 | |
| cris.virtual.author-orcid | 0000-0002-4385-0051 | |
| cris.virtualsource.author-orcid | 349c35ce-c6ee-4d8a-9a7f-b3aace65dbd7 | |
| cris.virtualsource.author-orcid | 48ec8e95-930e-4be2-b47a-b597e5d7440b | |
| dc.abstract.en | Background: Rosa canina L. (rosehip) is used worldwide in traditional medicine as a plant with medicinal properties. However, its anti-obesity effects are not fully explained on a transcriptional level. Methods: In the present work, the 3T3-L preadipocytes were utilized to explore the impact of R. canina fruit extract (RCE) on the cellular and molecular pathways involved in adipocyte hypertrophy. Results: Obtained results showed the ability of RCE to reduce lipid overloads in hypertrophic adipocytes associated with the down-regulation of mRNA expressions of adipogenic transcription factors such as PPARγ, C/EBPα, and SREBP-1c as well as genes involved in lipid biosyntheses such as FAS, LPL, and aP2. Moreover, obesity-associated oxidative stress (antioxidant enzyme activities and ROS generation) and inflammation were ameliorated in RCE-treated hypertrophic adipocytes. The mRNA and protein levels of adipokines such as leptin, resistin, and adiponectin were restored to more favorable levels. Conclusions: Rosa canina fruit might be a valuable source of phytochemicals in preventing obesity and obesity-related metabolic complications. | |
| dc.affiliation | Wydział Nauk o Żywności i Żywieniu | |
| dc.affiliation.institute | Katedra Biotechnologii i Mikrobiologii Żywności | |
| dc.contributor.author | Kowalska, Katarzyna | |
| dc.contributor.author | Olejnik, Anna | |
| dc.date.access | 2024-10-21 | |
| dc.date.accessioned | 2024-11-05T10:15:49Z | |
| dc.date.available | 2024-11-05T10:15:49Z | |
| dc.date.copyright | 2024-09-27 | |
| dc.date.issued | 2024 | |
| dc.description.abstract | <jats:p>Background: Rosa canina L. (rosehip) is used worldwide in traditional medicine as a plant with medicinal properties. However, its anti-obesity effects are not fully explained on a transcriptional level. Methods: In the present work, the 3T3-L preadipocytes were utilized to explore the impact of R. canina fruit extract (RCE) on the cellular and molecular pathways involved in adipocyte hypertrophy. Results: Obtained results showed the ability of RCE to reduce lipid overloads in hypertrophic adipocytes associated with the down-regulation of mRNA expressions of adipogenic transcription factors such as PPARγ, C/EBPα, and SREBP-1c as well as genes involved in lipid biosyntheses such as FAS, LPL, and aP2. Moreover, obesity-associated oxidative stress (antioxidant enzyme activities and ROS generation) and inflammation were ameliorated in RCE-treated hypertrophic adipocytes. The mRNA and protein levels of adipokines such as leptin, resistin, and adiponectin were restored to more favorable levels. Conclusions: Rosa canina fruit might be a valuable source of phytochemicals in preventing obesity and obesity-related metabolic complications.</jats:p> | |
| dc.description.accesstime | at_publication | |
| dc.description.bibliography | il., bibliogr. | |
| dc.description.finance | publication_nocost | |
| dc.description.financecost | 0.00 | |
| dc.description.if | 4,8 | |
| dc.description.number | 19 | |
| dc.description.points | 140 | |
| dc.description.version | final_published | |
| dc.description.volume | 16 | |
| dc.identifier.doi | 10.3390/nu16193269 | |
| dc.identifier.issn | 2072-6643 | |
| dc.identifier.uri | https://sciencerep.up.poznan.pl/handle/item/1985 | |
| dc.identifier.weblink | https://www.mdpi.com/2072-6643/16/19/3269 | |
| dc.language | en | |
| dc.relation.ispartof | Nutrients | |
| dc.relation.pages | art. 3269 | |
| dc.rights | CC-BY | |
| dc.sciencecloud | send | |
| dc.subject.en | Rosa canina | |
| dc.subject.en | hypertrophic adipocytes | |
| dc.subject.en | oxidative stress | |
| dc.subject.en | lipid accumulation | |
| dc.subject.en | inflammation | |
| dc.title | Rosehip Extract Decreases Reactive Oxygen Species Production and Lipid Accumulation in Hypertrophic 3T3-L1 Adipocytes with the Modulation of Inflammatory State | |
| dc.title.volume | Effects and Modulatory Mechanisms of Dietary Flavonoids in Obesity | |
| dc.type | JournalArticle | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 19 | |
| oaire.citation.volume | 16 |