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Bioactive Substances of Potato Juice Reveal Synergy in Cytotoxic Activity against Cancer Cells of Digestive System Studied In Vitro

cris.virtual.author-orcid0000-0002-0153-4624
cris.virtual.author-orcid0000-0002-4385-0051
cris.virtual.author-orcid0000-0002-9829-1541
cris.virtual.author-orcid0000-0001-7706-4035
cris.virtual.author-orcid0000-0003-3967-112X
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cris.virtualsource.author-orcid4ddc81ce-066b-4d2e-a9f3-015a6c34a525
cris.virtualsource.author-orcid48ec8e95-930e-4be2-b47a-b597e5d7440b
cris.virtualsource.author-orcid3a760071-6c31-4d98-b6b5-667cdf84f53d
cris.virtualsource.author-orcid349c35ce-c6ee-4d8a-9a7f-b3aace65dbd7
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cris.virtualsource.author-orcidb5ea5133-b916-419e-aa87-86a713721710
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dc.abstract.enMore and more literature data indicate the health-promoting effect of potato juice (PJ). However, to date, it has not been precisely explained which of the many compounds present in PJ exhibit biological activity. The work aimed to establish the antiproliferative effect of gastrointestinal digested PJ and the products of its processing. Fresh PJs derived from three edible potato varieties, industrial side stream resulting from starch production, partially deproteinized PJ derived from feed protein production line, and three different potato protein preparations subjected to digestion in the artificial gastrointestinal tract were used in this study. The cytotoxic potential of glycoalkaloids (GAs), phenolic acids, digested PJ, and products of PJ processing was determined in human normal and cancer cells derived from the digestive system. The results showed that GAs exhibit concentration-dependent cytotoxicity against all analyzed cell lines. In contrast, phenolic acids (caffeic, ferulic, and chlorogenic acid) do not show cytotoxicity in the applied cell lines. A correlation between cytotoxic potency and GAs content was found in all PJ products studied. The most potent effects were observed under treatment with deproteinized PJ, a product of industrial processing of PJ, distinguished by the highest effective activity among the fresh juice products studied. Moreover, this preparation revealed a favorable cytotoxicity ratio towards cancer cells compared to normal cells. Statistical analysis of the obtained results showed the synergistic effect of other bioactive substances contained in PJ and its products, which may be crucial in further research on the possibility of using PJ as a source of compounds of therapeutic importance.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Technologii Żywności Pochodzenia Roślinnego
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.contributor.authorKowalczewski, Przemysław Łukasz
dc.contributor.authorOlejnik, Anna
dc.contributor.authorWieczorek, Martyna N.
dc.contributor.authorZembrzuska, Joanna
dc.contributor.authorKowalska, Katarzyna
dc.contributor.authorLewandowicz, Jacek
dc.contributor.authorLewandowicz, Grażyna
dc.date.access2025-08-26
dc.date.accessioned2025-08-26T07:02:42Z
dc.date.available2025-08-26T07:02:42Z
dc.date.copyright2022-12-26
dc.date.issued2023
dc.description.abstract<jats:p>More and more literature data indicate the health-promoting effect of potato juice (PJ). However, to date, it has not been precisely explained which of the many compounds present in PJ exhibit biological activity. The work aimed to establish the antiproliferative effect of gastrointestinal digested PJ and the products of its processing. Fresh PJs derived from three edible potato varieties, industrial side stream resulting from starch production, partially deproteinized PJ derived from feed protein production line, and three different potato protein preparations subjected to digestion in the artificial gastrointestinal tract were used in this study. The cytotoxic potential of glycoalkaloids (GAs), phenolic acids, digested PJ, and products of PJ processing was determined in human normal and cancer cells derived from the digestive system. The results showed that GAs exhibit concentration-dependent cytotoxicity against all analyzed cell lines. In contrast, phenolic acids (caffeic, ferulic, and chlorogenic acid) do not show cytotoxicity in the applied cell lines. A correlation between cytotoxic potency and GAs content was found in all PJ products studied. The most potent effects were observed under treatment with deproteinized PJ, a product of industrial processing of PJ, distinguished by the highest effective activity among the fresh juice products studied. Moreover, this preparation revealed a favorable cytotoxicity ratio towards cancer cells compared to normal cells. Statistical analysis of the obtained results showed the synergistic effect of other bioactive substances contained in PJ and its products, which may be crucial in further research on the possibility of using PJ as a source of compounds of therapeutic importance.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if5,9
dc.description.number1
dc.description.points140
dc.description.versionfinal_published
dc.description.volume15
dc.identifier.doi10.3390/nu15010114
dc.identifier.issn2072-6643
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4348
dc.identifier.weblinkhttps://www.mdpi.com/2072-6643/15/1/114
dc.languageen
dc.relation.ispartofNutrients
dc.relation.pagesart. 114
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.ensolanine
dc.subject.enchaconine
dc.subject.enphenolic acids
dc.subject.enbiological activity
dc.subject.enSolanum tuberosum
dc.titleBioactive Substances of Potato Juice Reveal Synergy in Cytotoxic Activity against Cancer Cells of Digestive System Studied In Vitro
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume15