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Novel and Facile Green Synthesis of Copper Nanoparticles Using Aqueous Extract of Phragmites australis Leaves and Evaluation of their Antioxidant, Antihemolytic, Anti-inflammatory, and Anticancer Effects

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cris.virtualsource.author-orcid20597688-8be2-4b58-9e15-29f5ff8c53aa
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dc.abstract.enIntroduction: There is a growing interest in producing green nanoparticles with a variety of biological activities. For that, the leaf extract of Phragmites australis was used to mediate copper nanoparticle (CuNPs) synthesis, and its antioxidant, antihemolytic, anti-inflammatory, and anticancer effects were evaluated. Materials and Methods: The characterization of CuNPs was done using different techniques: UV-Vis spectroscopy, FT-IR spectroscopy, scanning and transmission electron microscopy (SEM and TEM), and X-ray diffraction. The antioxidant and anti-inflammatory activities were assessed using two methods for each. Anti-cancer potential was evaluated by means of the MTT assay. Results: Phytochemical screening demonstrated the richness of the plant in different biomolecules. UV-Vis spectra showed a peak at 312 nm. The crystalline structure of the phyto-synthesized CuNPs was confirmed by XRD, and the grain size was estimated to be 18.06 nm. Furthermore, the obtained nanoparticles exhibited remarkable antioxidant activity, with IC50 values of 4.62 µg/ml and 78.99 µg/ml for DPPH and FRAP tests, respectively. The IC50 values for the anti-inflammatory activity in both tests were conspicuous and revealed a substantial capability of green CuNPs. The cytotoxicity of Phragmites australis-mediated synthesized CuNPs against MCF-7 cell lines disclosed a dose-dependent efficacy. Conclusions: In conclusion, our research suggests that Phragmites australis leaves' aqueous extract can be used as reducing and stabilizing agents for the green synthesis of CuNPs, which provided antioxidant, anti-inflammatory, and anticancer effects.
dc.affiliationWydział Rolnictwa, Ogrodnictwa i Biotechnologii
dc.affiliation.instituteKatedra Genetyki i Hodowli Roślin
dc.contributor.authorFrahtia, Ahlem
dc.contributor.authorDerouiche, Samir
dc.contributor.authorNiemann, Janetta
dc.date.access2025-08-11
dc.date.accessioned2025-08-11T11:03:24Z
dc.date.available2025-08-11T11:03:24Z
dc.date.copyright2025-03-20
dc.date.issued2025
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.number1
dc.description.points20
dc.description.versionfinal_published
dc.description.volume12
dc.identifier.doi10.30491/jabr.2024.450158.1710
dc.identifier.eissn2423-5784
dc.identifier.issn2322-1186
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4131
dc.identifier.weblinkhttps://www.biotechrep.ir/article_219017.html
dc.languageen
dc.pbn.affiliationagriculture and horticulture
dc.relation.ispartofJournal of Applied Biotechnology Reports
dc.relation.pages1545-1553
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enPhragmites australis
dc.subject.engreen copper nanoparticle
dc.subject.enantioxidant
dc.subject.engrain size
dc.subject.encytotoxic activity
dc.titleNovel and Facile Green Synthesis of Copper Nanoparticles Using Aqueous Extract of Phragmites australis Leaves and Evaluation of their Antioxidant, Antihemolytic, Anti-inflammatory, and Anticancer Effects
dc.typeJournalArticle
dspace.entity.typePublication