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Biosynthesis of CuNP Using Phragmites australis Rhizomes: Biological Activity and Cytotoxicity Against MCF-7 Cell Line

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cris.virtualsource.author-orcid20597688-8be2-4b58-9e15-29f5ff8c53aa
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dc.abstract.enThe aim of this study was the use of rhizomes aqueous extract of Phragmites australis to mediate copper nanoparticles synthesis and evaluate their biological and pharmacological activities. The characteriza tion of the CuNPs was done using different techniques. The antioxidant and anti-inflammatory activities were assessed using two methods for each. Anti-cancer potential was evaluated by the means of MTT assay. UV-Vis spectra showed a peak at 300 nm. The crystalline structure of the phyto-synthesised CuNPs was confirmed by XRD and the grain size was estimated to be 19.76 nm. Further, the obtained nanoparticles exhibit a remarkable antioxidant activity, with IC50 values of 2.33 ± 0.22 µg/mL and 131.30 ± 0.67 µg/mL for DPPH and FRAP tests respectively. Values of IC50 for the anti-inflammatory activity in both tests were conspicuous and revealed a substantial capability of green CuNPs. The cytotoxicity of Phragmites australis mediated synthesized CuNPs against MCF-7 cell lines disclosed a dose dependent efficacy. Green synthesized CuNPs showed a promising antioxidant and anti-inflammatory activities and a prominent anti-cancer power at very small doses.
dc.abstract.languagees
dc.abstract.otherEl objetivo de este estudio fue el uso de extracto acuoso de rizomas de Phragmites australis para mediar la síntesis de nanopartículas de cobre y evaluar sus actividades biológicas y farmacológicas. La caracterización de las CuNPs se realizó utilizando diferentes técnicas. Las actividades antioxidantes y antiinflamatorias se evaluaron utilizando dos métodos para cada una. El potencial anticancerígeno se evaluó mediante el ensayo MTT. Los espectros UV-Vis mostraron un pico a 300 nm. La estructura cristalina de las CuNPs fitosintetizadas se confirmó por XRD y el tamaño de grano se estimó en 19,76 nm. Además, las nanopartículas obtenidas exhiben una notable actividad antioxidante, con valores de IC50 de 2,33 ± 0,22 µg/mL y 131,30 ± 0,67 µg/mL para las pruebas DPPH y FRAP respectivamente. Los valores de IC50 para la actividad antiinflamatoria en ambas pruebas fueron notables y revelaron una capacidad sustancial de las CuNP verdes. La citotoxicidad de las CuNP sintetizadas mediadas por Phragmites australis contra las líneas celulares MCF-7 reveló una eficacia dependiente de la dosis. Las CuNP verdes sintetizadas mostraron actividades antioxidantes y antiinflamatorias prometedoras y un destacado poder anticancerígeno en dosis muy pequeñas
dc.affiliationWydział Rolnictwa, Ogrodnictwa i Biotechnologii
dc.affiliation.instituteKatedra Genetyki i Hodowli Roślin
dc.contributor.authorAhlem, Frahtia
dc.contributor.authorDerouiche, Samir
dc.contributor.authorBoulaares, Islam
dc.contributor.authorNiemann, Janetta
dc.contributor.authorZolkapli, Eshak
dc.contributor.authorRadzi, Nur Fathiah Mohd
dc.contributor.authorKyaw, Htet Htet
dc.contributor.authorYounus, Hussein A
dc.contributor.authorAl-Abri, Mohammed
dc.date.accessioned2025-08-11T07:05:30Z
dc.date.available2025-08-11T07:05:30Z
dc.date.issued2025
dc.description.bibliographybibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if0,2
dc.description.number3
dc.description.points20
dc.description.volume44
dc.identifier.eissn2362-3853
dc.identifier.issn0326-2383
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4125
dc.identifier.weblinkhttp://www.latamjpharm.org/previous_issue.php?vol=44&num=3
dc.languageen
dc.pbn.affiliationagriculture and horticulture
dc.relation.ispartofLatin American Journal of Pharmacy
dc.relation.pages223-227
dc.rightsClosedAccess
dc.sciencecloudsend
dc.subject.enanti-inflammatory
dc.subject.enantioxidant
dc.subject.encharacterization
dc.subject.enCuNPs
dc.subject.encytotoxic activity
dc.subject.enPhragmites australis
dc.titleBiosynthesis of CuNP Using Phragmites australis Rhizomes: Biological Activity and Cytotoxicity Against MCF-7 Cell Line
dc.typeJournalArticle
dspace.entity.typePublication