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Comparison of different approaches for direct coupling of solid-phase microextraction to mass spectrometry for drugs of abuse analysis in plasma

cris.virtual.author-orcid0000-0002-9829-1541
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cris.virtualsource.author-orcid3a760071-6c31-4d98-b6b5-667cdf84f53d
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dc.abstract.enThe direct coupling of solid-phase microextraction (SPME) to mass spectrometry (MS) (SPME-MS) has proven to be an effective method for the fast screening and quantitative analysis of compounds in complex matrices such as blood and plasma. In recent years, our lab has developed three novel SPME-MS techniques: SPME-microfluidic open interface-MS (SPME-MOI-MS), coated blade spray-MS (CBS-MS), and SPME-probe electrospray ionization-MS (SPME-PESI-MS). The fast and high-throughput nature of these SPME-MS technologies makes them attractive options for point-of-care analysis and anti-doping testing. However, all these three techniques utilize different SPME geometries and were tested with different MS instruments. Lack of comparative data makes it difficult to determine which of these methodologies is the best option for any given application. This work fills this gap by making a comprehensive comparison of these three technologies with different SPME devices including SPME fibers, CBS blades, and SPME-PESI probes and SPME-liquid chromatography-MS (SPME-LC-MS) for the analysis of drugs of abuse using the same MS instrument. Furthermore, for the first time, we developed different desorption chambers for MOI-MS for coupling with SPME fibers, CBS blades, and SPME-PESI probes, thus illustrating the universality of this approach. In total, eight analytical methods were developed, with the experimental data showing that all the SPME-based methods provided good analytical performance with R2 of linearities larger than 0.9925, accuracies between 81% and 118%, and good precision with an RSD% 13%.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Technologii Żywności Pochodzenia Roślinnego
dc.contributor.authorZhou, Wei
dc.contributor.authorWieczorek, Martyna N.
dc.contributor.authorJiang, Runshan Will
dc.contributor.authorPawliszyn, Janusz
dc.date.access2025-07-04
dc.date.accessioned2025-09-15T10:35:36Z
dc.date.available2025-09-15T10:35:36Z
dc.date.copyright2022-11-09
dc.date.issued2023
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if6,1
dc.description.number2
dc.description.points140
dc.description.versionfinal_published
dc.description.volume13
dc.identifier.doi10.1016/j.jpha.2022.10.004
dc.identifier.eissn2214-0883
dc.identifier.issn2095-1779
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4792
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S2095177922001009?via%3Dihub
dc.languageen
dc.relation.ispartofJournal of Pharmaceutical Analysis
dc.relation.pages216-222
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.ensolid-phase microextraction
dc.subject.enmass spectrometry
dc.subject.enmicrofluidic open interface
dc.subject.encoated blade spray
dc.subject.enprobe electrospray ionization
dc.subject.endrug of abuse
dc.subtypeScientificCommunication
dc.titleComparison of different approaches for direct coupling of solid-phase microextraction to mass spectrometry for drugs of abuse analysis in plasma
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.volume13