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Effects of ovariectomy and calcium enriched pumpkin on magnesium status in rats

cris.virtual.author-orcid0000-0002-0744-9033
cris.virtual.author-orcid0000-0002-0937-8427
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid968d3cb8-3b2b-46fe-a17f-373169a0738c
cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enBackground. Calcium (Ca) and magnesium (Mg) are important components of bones, whose homeostasis is disturbed during menopause. Calcium and magnesium metabolism are closely related, so it is important to study the interactions between them. This study aimed to determine the effect of Ca-enriched pumpkin on the Mg content in tissues in an animal model of postmenopausal osteoporosis. Material and methods. 70 female Wistar rats divided into seven groups. One group was fed a standard diet (C), whereas the other six groups were ovariectomized and fed a standard diet (OVX), a calcium-deficient diet (DEF), a calcium lactate diet (CaL), calcium-lactate-enriched pumpkin (P_CaL), calcium lactate and alendronate (CaL_B), or calcium-lactate-enriched pumpkin and alendronate (P_CaL_B). This nutritional intervention was followed for 12 weeks, and then the rats were euthanized. Tissue samples were collected, and their magnesium content was assessed. Results. The Mg content in bones was lower in the OVX group (3.15 ±0.19 mg/g) but higher in the DEF group (3.76 ±0.16 mg/g) in comparison with the control group (3.45 ±0.15 mg/g). The Mg content in the muscles and the liver was higher in the P_CaL group (1025.24 ±47.22 μg/g and 2102.09 ±83.35 μg/g) compared with the control group (842.51 ±19.13 μg/g and 1486.15 ±97.12 μg/g). However, the CaL_B and P_CaL_B groups showed a high Mg content in the kidneys (about 156% of the control group). Conclusion. Ovariectomy and intervention diets revealed various new observations regarding the effect of innovative calcium-rich foods on the Mg content. These results showed that (i) ovariectomy decreases the status of Mg content; (ii) deficiency of Ca in the diet and Ca-enriched pumpkin with alendronate improve the Mg content in bones; and (iii) alendronate promotes the accumulation of Mg in the kidneys. In postmenopausal women, both those treated and untreated with drugs and diet, magnesium status should be monitored.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Technologii Gastronomicznej i Żywności Funkcjonalnej
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorWawrzyniak, Natalia
dc.contributor.authorGramza-Michałowska, Anna
dc.contributor.authorSuliburska, Joanna
dc.date.access2025-12-08
dc.date.accessioned2025-12-09T13:22:24Z
dc.date.available2025-12-09T13:22:24Z
dc.date.copyright2023-01-09
dc.date.issued2022
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if1,5
dc.description.number4
dc.description.points40
dc.description.versionfinal_published
dc.description.volume21
dc.identifier.doi10.17306/J.AFS.1108
dc.identifier.eissn1898-9594
dc.identifier.issn1644-0730
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6284
dc.identifier.weblinkhttps://www.food.actapol.net/volume21/issue4/abstract-9.html
dc.languageen
dc.relation.ispartofActa Scientiarum Polonorum, Technologia Alimentaria
dc.relation.pages439–448
dc.rightsCC-BY-NC
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enovariectomy
dc.subject.encalcium
dc.subject.enmagnesium
dc.subject.enpostmenopausal osteoporosis
dc.subject.enovariectomized rats
dc.titleEffects of ovariectomy and calcium enriched pumpkin on magnesium status in rats
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.volume21