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Dietary salicylates affect calcium and magnesium status in preeclampsia model rats induced by NG-nitro-L-arginine-methyl ester (L-NAME)

cris.lastimport.scopus2025-10-23T06:57:36Z
cris.virtual.author-orcid0000-0002-4173-5965
cris.virtual.author-orcid0000-0003-4113-1595
cris.virtual.author-orcid0000-0002-0937-8427
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcidc8f75a2c-3403-4f93-aa73-6cf0ae8b543d
cris.virtualsource.author-orcide5b3bdcc-fb9a-4a83-9a35-c24812d69ccd
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enPreeclampsia (PE) represents a complex hypertensive disorder of pregnancy which combines blood pressure elevation with organ dysfunction through mineral metabolism disturbances. The current guidelines recommend low-dose aspirin for PE prevention yet the impact of dietary salicylates on mineral status remains an open question. This research investigated how dietary salicylates and aspirin affect calcium and magnesium homeostasis in rats with NG-nitro-L-arginine-methyl ester (L-NAME)-induced preeclampsia. The research involved pregnant Sprague Dawley rats who received six different treatment groups: CH (healthy controls) and PE (preeclamptic controls) alongside four intervention groups that combined L-NAME with low or high dietary salicylates (LSP, HSP) or aspirin (LAP, HAP). The preeclampsia model used L-NAME (0.5 mg/mL) throughout gestational days 6–19. The flame atomic absorption spectrometry method measured calcium and magnesium levels in tissues and serum samples. The high-performance liquid chromatography (HPLC) and the ultra-high performance liquid chromatography-tandem mass spectrometry system (UHPLC-MS/MS) analyzed salicylic acid concentrations. The administration of L-NAME resulted in elevated blood pressure together with elevated calcium levels in placental and renal tissues. The tissue magnesium (Mg) levels increased in heart and brain tissues when animals consumed salicylates or aspirin without any effect on blood pressure. The combination of high salicylate intake resulted in reduced calcium (Ca) levels in femoral tissues and decreased albumin excretion in urine. The Ca:Mg molar ratio changed significantly in kidney tissue as well as placenta tissue and pancreas tissue. The preeclampsia condition caused by L-NAME disrupts the normal distribution of calcium and magnesium throughout maternal and fetal body tissues.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliationWydział Leśny i Technologii Drewna
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.affiliation.instituteKatedra Chemii
dc.contributor.authorCholik, Rafsan Syabani
dc.contributor.authorSkrypnik, Katarzyna
dc.contributor.authorKaraźniewicz-Łada, Marta
dc.contributor.authorWaśkiewicz, Agnieszka
dc.contributor.authorSuliburska, Joanna
dc.date.access2025-08-13
dc.date.accessioned2025-08-13T12:40:47Z
dc.date.available2025-08-13T12:40:47Z
dc.date.copyright2025-08-06
dc.date.issued2025
dc.description.accesstimeat_publication
dc.description.bibliographybibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,3
dc.description.numberOctober 2025
dc.description.points100
dc.description.versionfinal_published
dc.description.volume91
dc.identifier.doi10.1016/j.jtemb.2025.127711
dc.identifier.eissn1878-3252
dc.identifier.issn0946-672X
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4212
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S0946672X25001245
dc.languageen
dc.relation.ispartofJournal of Trace Elements in Medicine and Biology
dc.relation.pagesart. 127711
dc.relation.projectŻywieniowe źródła salicylanów a zaburzenia angiogenezy łożyska w preeklampsji
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOTHER
dc.subject.enaspirin
dc.subject.encalcium
dc.subject.endietary salicylates
dc.subject.enL-NAME
dc.subject.enmagnesium
dc.subject.enpreeclampsia
dc.titleDietary salicylates affect calcium and magnesium status in preeclampsia model rats induced by NG-nitro-L-arginine-methyl ester (L-NAME)
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume91