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A meta-analysis of the effects and relationship between guanidinoacetic acid and the growth performance of broiler chickens

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dc.abstract.enRegulating dietary Arginine (Arg) levels in the diet of broilers has been a focus of researchers due to the potential economic benefit to the industry. This meta-analysis evaluated the effects of dietary guanidinoacetic acid (GAA) supplementation on the production performance of broiler chickens fed diets that were either adequate or deficient in Arg or energy. Through studies, the basal diet generally met standard requirements for broilers, with deficiencies in Arg or energy being experientially induced. The meta-analysis using weighted random-effects models revealed that dietary GAA improved average daily gain (ADG; P < 0.001) by 2.17% and 1.08% during starter and finisher periods, respectively. Concomitantly, the feed conversion ratio (FCR; P < 0.001) also improved by 2.37% and 2.41% in the starter and finisher periods, respectively, with minimal evidence of publication bias for these key traits. However, significant heterogeneity (I² > 90%) indicated strong between-study variances. In broilers fed Arg-deficient diets, GAA supplementation only showed minimal effect to reduce the detrimental effect of an Arg-deficient diet (-4.75 vs. -3.64% ADG reduction), suggesting its limited Arg-sparing function. Under low energy diet, GAA restored ADG to levels equivalent to those of energy-sufficient diets. In the finisher phase, comparable but less pronounced effects were observed, suggesting reduced responsiveness with age. Dose-response evaluation suggested no difference in ADG or FCR between low and high GAA inclusion, suggesting low GAA level is more effective. Meta-regression models identified feed intake and arginine intake as the dominant predictors of ADG, and including GAA consistently improved model accuracy and increased ADG compared to the control diet. The meta-refgression suggested that 0.06% GAA supplementation increased final body weight by approximately 2.11% (60 g) in Ross 308 broilers. Collectively, the results confirm that GAA exerts a robust, dose-limited benefit of growth efficiency in broiler chickens, thereby supporting its incorporation into Arg or energy deficient diets that would have potential economic benefit.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Żywienia Zwierząt
dc.contributor.authorGao, Min
dc.contributor.authorEl-Sherbiny, Mohamed
dc.contributor.authorKierończyk, Bartosz
dc.contributor.authorGuo, Hao
dc.contributor.authorAli, Montaser Elsayed
dc.contributor.authorAbdel-Moneim, Abdel Moneim Eid
dc.contributor.authorPurba, Mhd. Adanan
dc.contributor.authorPradista, Luthfi Adya
dc.contributor.authorSaputro, Wahyu Subagio
dc.contributor.authorRatriyanto, Adi
dc.contributor.authorSuprayogi, Wara Pratitis Sabar
dc.contributor.authorYanza, Yulianri Rizki
dc.contributor.authorIrawan, Agung
dc.date.access2026-03-04
dc.date.accessioned2026-03-04T08:53:33Z
dc.date.available2026-03-04T08:53:33Z
dc.date.copyright2026-02-22
dc.date.issued2026
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibligr.
dc.description.financepublication_nocost
dc.description.financecost0.00
dc.description.if4,2
dc.description.number5
dc.description.points140
dc.description.versionfinal_published
dc.description.volume105
dc.identifier.doi10.1016/j.psj.2026.106692
dc.identifier.eissn1525-3171
dc.identifier.issn0032-5791
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7600
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S003257912600307X
dc.languageen
dc.pbn.affiliationanimal science and fisheries
dc.relation.ispartofPoultry Science
dc.relation.pagesart. 106692
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enarginine
dc.subject.enbroiler nutrition
dc.subject.encreatine
dc.subject.enmeta-regression
dc.titleA meta-analysis of the effects and relationship between guanidinoacetic acid and the growth performance of broiler chickens
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue5
oaire.citation.volume105