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Meta-analysis of genome-wide association studies for litter size in pigs indicates new causal variants

Type
Monograph chapter conference
Language
English
Date issued
2022
Author
Sell-Kubiak, Ewa 
Derks, M.F.L.
Lopes, M.S.
Dobrzański, J.
Szwaczkowski, Tomasz 
Editor
Veerkamp, R. F.
de Haas, Y.
Faculty
Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
DOI
10.3920/978-90-8686-940-4_514
Web address
https://brill.com/edcollbook-oa/title/68845
Publisher ministerial
Wageningen Academic Publishers
Pages from-to
2134-2137
Monograph title
Proceedings of the 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
Abstract (EN)
The aim of this study was the meta-analysis (MA) of five GWAS for total number born (TNB) coming from five pig populations. MA was performed in METAL based on weighted Z-scores. As a result, two new SNPs were discovered that were not reported before as associated with TNB. First, on Sus scrofa chromosome (SSC) 14 located in intron of FAM13C gene. Second, on SSC9 located within intron of AGMO gene. pCADD analysis revealed a strong candidate causal gene underlying the QTL on SSC9. The third best hit and the most promising candidate gene for litter size was found within the SOSTDC1 gene associated with lower male fertility in rats.
License
cc-bycc-by CC-BY - Attribution
Open access date
2022