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Meta-analysis of genome-wide association studies for litter size in pigs indicates new causal variants

cris.virtual.author-orcid0000-0002-7642-0787
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cris.virtual.author-orcid0000-0003-4233-8803
cris.virtualsource.author-orcidfc57cf04-e023-4b05-9241-1c5d72ef234b
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cris.virtualsource.author-orcid4207065a-66be-4361-8290-3aa02454b4df
dc.abstract.enThe aim of this study was the meta-analysis (MA) of five GWAS for total number born (TNB) coming from five pig populations. MA was performed in METAL based on weighted Z-scores. As a result, two new SNPs were discovered that were not reported before as associated with TNB. First, on Sus scrofa chromosome (SSC) 14 located in intron of FAM13C gene. Second, on SSC9 located within intron of AGMO gene. pCADD analysis revealed a strong candidate causal gene underlying the QTL on SSC9. The third best hit and the most promising candidate gene for litter size was found within the SOSTDC1 gene associated with lower male fertility in rats.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Genetyki i Podstaw Hodowli Zwierząt​​
dc.contributor.authorSell-Kubiak, Ewa
dc.contributor.authorDerks, M.F.L.
dc.contributor.authorLopes, M.S.
dc.contributor.authorDobrzański, J.
dc.contributor.authorSzwaczkowski, Tomasz
dc.contributor.editorVeerkamp, R. F.
dc.contributor.editorde Haas, Y.
dc.date.access2026-01-14
dc.date.accessioned2026-01-16T09:48:17Z
dc.date.available2026-01-16T09:48:17Z
dc.date.copyright2022
dc.date.issued2022
dc.description.accesstimeat_publication
dc.description.bibliographybibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.versionfinal_published
dc.identifier.doi10.3920/978-90-8686-940-4_514
dc.identifier.isbn978-90-8686-940-4
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6944
dc.identifier.weblinkhttps://brill.com/edcollbook-oa/title/68845
dc.languageen
dc.pubinfoThe Netherlands
dc.publisher.ministerialWageningen Academic Publishers
dc.relation.bookProceedings of the 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
dc.relation.pages2134-2137
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typePUBLISHER_WEBSITE
dc.titleMeta-analysis of genome-wide association studies for litter size in pigs indicates new causal variants
dc.typeMonographChapterConference
dspace.entity.typePublication