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Single Nucleotide Polymorphism and mRNA Expression of LTF in Oral Squamous Cell Carcinoma

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dc.abstract.enOral squamous cell carcinoma (OSCC) is one of the most prevalent types of cancers worldwide. LTF arrests the G1 to S phase transition of the cell cycle. This study is the first that has aimed to determine the possible association between the LTF polymorphisms (rs2073495, rs1126478, rs34827868, rs1042073, rs4637321, rs2239692 and rs10865941), the mRNA LTF expression, the risk of OSCC and the influence on the TNM staging and histological grading. This study was composed of 176 Polish patients, including 88 subjects diagnosed with OSCC and 88 healthy individuals. QuantStudio Design and Analysis Software v1.5.1 was used for the single nucleotide polymorphism (SNP) analysis and mRNA LTF expression. The G/G genotype of rs2073495 and the G/G genotype of rs4637321 were linked, with an increased risk of OSCC. There were no significant influences between the TNM staging and the histological grading and the LTF genotype. We found no statistically significant dissimilarities in the expression level of LTF genes in the tumour and margin specimens. No association was found between the gene expression levels, the other parameters or LTF polymorphisms in the tumour and margin samples. In conclusion, rs2073495 and rs4637321 polymorphisms may affect the risk of OSCC. These results should be validated on larger and different cohorts to better comprehend the role of the LTF gene in OSCC.
dc.affiliationWydział Leśny i Technologii Drewna
dc.affiliation.instituteKatedra Urządzania Lasu
dc.contributor.authorGołąbek, Karolina
dc.contributor.authorRączka, Grzegorz
dc.contributor.authorGaździcka, Jadwiga
dc.contributor.authorMiśkiewicz-Orczyk, Katarzyna
dc.contributor.authorZięba, Natalia
dc.contributor.authorKrakowczyk, Łukasz
dc.contributor.authorHudy, Dorota
dc.contributor.authorAsman, Marek
dc.contributor.authorMisiołek, Maciej
dc.contributor.authorStrzelczyk, Joanna Katarzyna
dc.date.access2026-02-18
dc.date.accessioned2026-03-03T13:33:26Z
dc.date.available2026-03-03T13:33:26Z
dc.date.copyright2022-11-10
dc.date.issued2022
dc.description.abstract<jats:p>Oral squamous cell carcinoma (OSCC) is one of the most prevalent types of cancers worldwide. LTF arrests the G1 to S phase transition of the cell cycle. This study is the first that has aimed to determine the possible association between the LTF polymorphisms (rs2073495, rs1126478, rs34827868, rs1042073, rs4637321, rs2239692 and rs10865941), the mRNA LTF expression, the risk of OSCC and the influence on the TNM staging and histological grading. This study was composed of 176 Polish patients, including 88 subjects diagnosed with OSCC and 88 healthy individuals. QuantStudio Design and Analysis Software v1.5.1 was used for the single nucleotide polymorphism (SNP) analysis and mRNA LTF expression. The G/G genotype of rs2073495 and the G/G genotype of rs4637321 were linked, with an increased risk of OSCC. There were no significant influences between the TNM staging and the histological grading and the LTF genotype. We found no statistically significant dissimilarities in the expression level of LTF genes in the tumour and margin specimens. No association was found between the gene expression levels, the other parameters or LTF polymorphisms in the tumour and margin samples. In conclusion, rs2073495 and rs4637321 polymorphisms may affect the risk of OSCC. These results should be validated on larger and different cohorts to better comprehend the role of the LTF gene in OSCC.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographybibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,5
dc.description.number11
dc.description.points100
dc.description.versionfinal_published
dc.description.volume13
dc.identifier.doi10.3390/genes13112085
dc.identifier.issn2073-4425
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7596
dc.identifier.weblinkhttps://www.mdpi.com/2073-4425/13/11/2085
dc.languageen
dc.relation.ispartofGenes
dc.relation.pagesart. 2085
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enLTF
dc.subject.enoral squamous cell carcinoma
dc.subject.ensingle nucleotide polymorphism
dc.titleSingle Nucleotide Polymorphism and mRNA Expression of LTF in Oral Squamous Cell Carcinoma
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue11
oaire.citation.volume13