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Cleft Lip and Palate in Four Full-Sib Puppies from a Single Litter of Staffordshire Bull Terrier Dogs: An Anatomical and Genetic Study

cris.virtual.author-orcid0000-0002-1256-0107
cris.virtual.author-orcid0000-0002-1041-3576
cris.virtual.author-orcid0000-0002-1820-5202
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cris.virtual.author-orcid0000-0001-9683-3514
cris.virtual.author-orcid0000-0002-7227-0654
cris.virtual.author-orcid0000-0003-0715-0223
cris.virtual.author-orcid0000-0003-2539-9508
cris.virtual.author-orcid0000-0002-1126-1084
cris.virtual.author-orcid0000-0002-4238-0414
cris.virtualsource.author-orcid0320b45e-cc98-4201-88f2-602b5dfa2a20
cris.virtualsource.author-orcidb1f9951f-b018-4795-8cff-c7188dd69448
cris.virtualsource.author-orcid9fd4d04e-0912-425f-812f-aab2e3debe36
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid0462016b-1c5d-4a1f-990b-6b10579539c4
cris.virtualsource.author-orcidad732626-b998-4c32-a9dc-82d9928533d8
cris.virtualsource.author-orcid0c22ceb5-e5c6-4f5d-a0fd-8ec91a16efa9
cris.virtualsource.author-orcid5b5c83e3-837f-42d1-855b-f39952dd433b
cris.virtualsource.author-orcid2a8e4a28-71d4-41a8-bb3e-8d4141751d62
cris.virtualsource.author-orcid30dfea4c-e71f-4891-8e23-aafe00ca70e0
dc.abstract.enCleft lip and palate (CLP) is a well-known congenital defect in dogs, characterized by abnormal communication between the oral and nasal cavities. Its incidence rate is high and affects all dog breeds. The etiology of CLP is thought to be multifactorial, caused by both genetic and environmental factors. In this study, four puppies out of seven from a single litter of Staffordshire Bull Terrier dogs with craniofacial abnormalities were anatomically and genetically examined. Classical anatomical preparation, dyed-latex-injection of the arterial vessels, and cone-beam computed tomography were used. The puppies showed variations in their observable abnormalities: three of them had a complete cleft of the palate on both sides, while one puppy had a cleft on the right side only. Cytogenetic analysis showed a normal diploid chromosome number (2n = 78,XX or 78,XY) in the studied animals. Known genomic variants of CLP were examined in the ADAMTS20, DLX6, and MYH3 genes, but no mutations were identified. Further studies are needed to identify the breed-specific genetic variants associated with canine CLP.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliationUniwersyteckie Centrum Medycyny Weterynaryjnej
dc.affiliation.instituteKatedra Genetyki i Podstaw Hodowli Zwierząt​​
dc.affiliation.instituteKatedra Nauk Przedklinicznych i Chorób Zakaźnych
dc.affiliation.instituteKatedra Fizjologii, Biochemii i Biostruktury Zwierząt
dc.contributor.authorRuszkowski, Jakub Jędrzej
dc.contributor.authorNowacka-Woszuk, Joanna
dc.contributor.authorNowak, Tomasz
dc.contributor.authorRozynek, Jędrzej
dc.contributor.authorSerwańska-Leja, Katarzyna
dc.contributor.authorGogulski, Maciej
dc.contributor.authorKołodziejski, Paweł Antoni
dc.contributor.authorŚwitoński, Marek
dc.contributor.authorZdun, Maciej
dc.contributor.authorSzczerbal, Izabela
dc.date.access2025-06-02
dc.date.accessioned2025-09-04T07:22:44Z
dc.date.available2025-09-04T07:22:44Z
dc.date.copyright2023-08-29
dc.date.issued2023
dc.description.abstract<jats:p>Cleft lip and palate (CLP) is a well-known congenital defect in dogs, characterized by abnormal communication between the oral and nasal cavities. Its incidence rate is high and affects all dog breeds. The etiology of CLP is thought to be multifactorial, caused by both genetic and environmental factors. In this study, four puppies out of seven from a single litter of Staffordshire Bull Terrier dogs with craniofacial abnormalities were anatomically and genetically examined. Classical anatomical preparation, dyed-latex-injection of the arterial vessels, and cone-beam computed tomography were used. The puppies showed variations in their observable abnormalities: three of them had a complete cleft of the palate on both sides, while one puppy had a cleft on the right side only. Cytogenetic analysis showed a normal diploid chromosome number (2n = 78,XX or 78,XY) in the studied animals. Known genomic variants of CLP were examined in the ADAMTS20, DLX6, and MYH3 genes, but no mutations were identified. Further studies are needed to identify the breed-specific genetic variants associated with canine CLP.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if2,7
dc.description.number17
dc.description.points100
dc.description.versionfinal_published
dc.description.volume13
dc.identifier.doi10.3390/ani13172749
dc.identifier.issn2076-2615
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4611
dc.identifier.weblinkhttp://www.mdpi.com/2076-2615/13/17/2749
dc.languageen
dc.relation.ispartofAnimals
dc.relation.pagesart. 2749
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enADAMTS20
dc.subject.encleft lip
dc.subject.encongenital malformation
dc.subject.enDLX6
dc.subject.endog
dc.subject.engenes
dc.subject.enMYH3
dc.subject.enpalatal clefts
dc.subtypeCaseStudy
dc.titleCleft Lip and Palate in Four Full-Sib Puppies from a Single Litter of Staffordshire Bull Terrier Dogs: An Anatomical and Genetic Study
dc.title.volumeSpecial Issue Advances in Companion Animal Clinical Pathology
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue17
oaire.citation.volume13