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Antiplatelet potencies of polysaccharides extracted from eight cultivated edible Pleurotus mushroom species

cris.virtual.author-orcid0000-0001-7185-5039
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cris.virtualsource.author-orcid8786358f-edf5-4c7f-84cf-56861e61928f
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cris.virtualsource.author-orcid5fdbcecb-f41c-44db-a313-f0f38de3f651
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enBackground Cardiovascular diseases remain a leading global health challenge, necessitating effective antiplatelet therapies to mitigate thrombotic risks. Conventional antiplatelet agents, such as acetylsalicylic acid (ASA) and purinergic receptor type Y, subtype 12 (P2Y12) inhibitors, are effective but present limitations, including bleeding complications and resistance in some patients. This study investigates the antiplatelet potential of polysaccharide fractions extracted from fruiting bodies of eight different edible Pleurotus mushroom species cultivated for the purpose of this research. Methods Mushroom polysaccharide fractions were extracted from eight Pleurotus species (P. citrinopileatus, P. columbinus, P. djamor, P. eryngii, P. florida, P. ostreatus, P. pulmonarius, and P. sajor-caju) with cold water. Using multiple electrode aggregometry, we evaluated their inhibitory effects on platelet aggregation induced by adenosine-5′-diphosphate (ADP) and arachidonic acid (AA). Results Polysaccharides from all tested Pleurotus species exhibit significant inhibition of ADP-induced platelet aggregation in the 69–75% range, comparable to or exceeding that of ASA. While their beneficial effect on AA-induced aggregation was lower and limited to selected species with inhibition in the 6–46% range, polysaccharides from P. djamor and P. sajor-caju demonstrated promising dual inhibition. Conclusions This study suggests that Pleurotus-derived polysaccharides may serve as potential natural alternatives or adjuncts to existing antiplatelet therapies. Further in vivo studies and clinical trials are warranted to investigate their therapeutic potential in the prevention and management of cardiovascular disease.
dc.affiliationWydział Rolnictwa, Ogrodnictwa i Biotechnologii
dc.affiliationWydział Inżynierii Środowiska i Inżynierii Mechanicznej
dc.affiliation.instituteKatedra Warzywnictwa
dc.affiliation.instituteKatedra Ekologii i Ochrony Środowiska
dc.contributor.authorPoniedziałek, Barbara
dc.contributor.authorSiwulski, Marek
dc.contributor.authorKomaniecka, Iwona
dc.contributor.authorWiater, Adrian
dc.contributor.authorChoma, Adam
dc.contributor.authorRosińska, Joanna
dc.contributor.authorFrąszczak, Barbara
dc.contributor.authorRzymski, Piotr
dc.date.accessioned2025-07-21T08:12:05Z
dc.date.available2025-07-21T08:12:05Z
dc.date.issued2025
dc.description.bibliographybibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,8
dc.description.number4
dc.description.points100
dc.description.volume77
dc.identifier.doi10.1007/s43440-025-00726-5
dc.identifier.eissn2299-5684
dc.identifier.issn1734-1140
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/3906
dc.languageen
dc.pbn.affiliationagriculture and horticulture
dc.pbn.affiliationenvironmental engineering, mining and energy
dc.relation.ispartofPharmacological Reports
dc.relation.pages1109–1118
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enhuman platelets
dc.subject.encardiovascular disease
dc.subject.enantiplatelet agents
dc.subject.enPleurotus mushrooms
dc.subject.enfunctional foods
dc.titleAntiplatelet potencies of polysaccharides extracted from eight cultivated edible Pleurotus mushroom species
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.volume77