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Association between the Concentrations of Essential and Toxic Elements in Mid-Trimester Amniotic Fluid and Fetal Chromosomal Abnormalities in Pregnant Polish Women

cris.virtual.author-orcid0000-0002-0937-8427
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cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
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dc.abstract.enThe present study aimed to investigate the relationship between the concentrations of essential and toxic elements present in the amniotic fluid (AF) and fetal chromosomal abnormalities in pregnant women. A total of 156 pregnant white Polish women aged between 20 and 43 years and screened to detect high risk for chromosomal defects in the first trimester were included in the study. AF samples were collected from these women during routine diagnostic and treatment procedures at mid-gestation (15–22 weeks of their pregnancies). The concentrations of various minerals in the AF were determined by inductively coupled plasma mass spectrometry. Genomic hybridization and cytogenetic karyotyping were performed to detect chromosomal aberrations in the fetuses. The genetic analysis revealed chromosomal aberrations in 19 fetuses (over 12% of all the evaluated women). The major abnormalities identified were trisomy 21 (N = 11), trisomy 18 (N = 2), and triploidy (N = 2). Fetuses with chromosomal abnormalities more frequently showed lower manganese concentration in the AF in the second trimester as compared to those with normal karyotype. A coincidence was observed between high iron levels in the AF and a higher risk of chromosomal abnormalities in the fetuses.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorSuliburska, Joanna
dc.contributor.authorPankiewicz, Jakub
dc.contributor.authorSajnóg, Adam
dc.contributor.authorPaczkowska, Magdalena
dc.contributor.authorNowakowska, Beata
dc.contributor.authorBakinowska, Ewa
dc.contributor.authorBarałkiewicz, Danuta
dc.contributor.authorKocyłowski, Rafał
dc.date.access2026-02-03
dc.date.accessioned2026-02-20T08:19:40Z
dc.date.available2026-02-20T08:19:40Z
dc.date.copyright2022-04-13
dc.date.issued2022
dc.description.abstract<jats:p>The present study aimed to investigate the relationship between the concentrations of essential and toxic elements present in the amniotic fluid (AF) and fetal chromosomal abnormalities in pregnant women. A total of 156 pregnant white Polish women aged between 20 and 43 years and screened to detect high risk for chromosomal defects in the first trimester were included in the study. AF samples were collected from these women during routine diagnostic and treatment procedures at mid-gestation (15–22 weeks of their pregnancies). The concentrations of various minerals in the AF were determined by inductively coupled plasma mass spectrometry. Genomic hybridization and cytogenetic karyotyping were performed to detect chromosomal aberrations in the fetuses. The genetic analysis revealed chromosomal aberrations in 19 fetuses (over 12% of all the evaluated women). The major abnormalities identified were trisomy 21 (N = 11), trisomy 18 (N = 2), and triploidy (N = 2). Fetuses with chromosomal abnormalities more frequently showed lower manganese concentration in the AF in the second trimester as compared to those with normal karyotype. A coincidence was observed between high iron levels in the AF and a higher risk of chromosomal abnormalities in the fetuses.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,6
dc.description.number4
dc.description.points70
dc.description.versionfinal_published
dc.description.volume12
dc.identifier.doi10.3390/diagnostics12040979
dc.identifier.issn2075-4418
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7401
dc.identifier.weblinkhttps://www.mdpi.com/2075-4418/12/4/979
dc.languageen
dc.relation.ispartofDiagnostics
dc.relation.pagesart. 979
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enpregnancy
dc.subject.enelements
dc.subject.enamniotic fluid
dc.subject.enchromosomal abnormalities
dc.titleAssociation between the Concentrations of Essential and Toxic Elements in Mid-Trimester Amniotic Fluid and Fetal Chromosomal Abnormalities in Pregnant Polish Women
dc.title.volumeSpecial Issue Diagnosis and Management in Prenatal Medicine
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.volume12