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The effect of 12-week high-dose Colostrum Bovinum supplementation on immunological, hematological and biochemical markers in endurance athletes: a randomized crossover placebo-controlled study

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dc.abstract.enBackground: Bovine colostrum (COL) is assumed to be one of the strongest natural immune stimulants. Regular ingestion of COL may contribute to improved immune response in athletes exposed to high training loads. Methods: Twenty-eight endurance-trained males aged 31.1 ± 10.2 years (body mass 81.9 ± 9.0 kg; height 1.82 ± 0.06 m) completed this randomized double-blind placebo(PLA)-controlled crossover study aimed at investigating the effect of 12-week COL supplementation (25gCOL·day-1) on resting (REST), exercise-induced (POST-EX), and short-term post-exercise recovery (REC; 1 h after test exercise) changes in selected saliva and blood immunoglobulins (Ig), white blood cell (WBC) count and differential; as well as blood hematological, nutritional status and muscle damage indices. The protocol assumed 4 study visits – before/after supplementation with COL (COLPRE and COLPOST) and PLA (PLAPRE and PLAPOST). During testing sessions, incremental rowing test to exhaustion and swimming-specific performance test were introduced as exercise stimuli. Results: At COLPOST visit the secretory IgA (SIgA) concentration in saliva was significantly higher at POST-EX and REC compared to REST (p<0.05). COL supplementation had no effect on blood IgA, IgE, IgD, IgG, and IgM concentrations. Furthermore, after COL supplementation decrease of hematocrit at REC (p<0.05) was revealed. Conclusions: 12-week supplementation with 25 gCOL·day-1 in endurance-trained male athletes resulted in a favorable increase in post-exercise concentration of salivary SIgA. COL seems to be a potential stimulator of local immune defense after exercise-induced homeostasis disturbances. Nevertheless, the lack of effect on blood markers indicates the need for further research in the area of mechanisms underlying the effect of the supposed COL immunological capacity.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorDurkalec-Michalski, Krzysztof
dc.contributor.authorGłówka, Natalia
dc.contributor.authorPodgórski, Tomasz
dc.contributor.authorWoźniewicz, Małgorzata
dc.contributor.authorNowaczyk, Paulina M.
dc.date.access2024-11-19
dc.date.accessioned2024-11-19T09:48:36Z
dc.date.available2024-11-19T09:48:36Z
dc.date.copyright2024-10-21
dc.date.issued2024
dc.description.abstract<jats:sec><jats:title>Background</jats:title><jats:p><jats:italic>Bovine colostrum</jats:italic> (COL) is assumed to be one of the strongest natural immune stimulants. Regular ingestion of COL may contribute to improved immune response in athletes exposed to high training loads.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Twenty-eight endurance-trained males aged 31.1 ± 10.2 years (body mass 81.9 ± 9.0 kg; height 1.82 ± 0.06 m) completed this randomized double-blind placebo(PLA)-controlled crossover study aimed at investigating the effect of 12-week COL supplementation (25g<jats:sub>COL</jats:sub>·day<jats:sup>-1</jats:sup>) on resting (REST), exercise-induced (POST-EX), and short-term post-exercise recovery (REC; 1 h after test exercise) changes in selected saliva and blood immunoglobulins (Ig), white blood cell (WBC) count and differential; as well as blood hematological, nutritional status and muscle damage indices. The protocol assumed 4 study visits – before/after supplementation with COL (<jats:italic>COL<jats:sub>PRE</jats:sub></jats:italic> and <jats:italic>COL<jats:sub>POST</jats:sub></jats:italic>) and PLA (<jats:italic>PLA<jats:sub>PRE</jats:sub></jats:italic> and <jats:italic>PLA<jats:sub>POST</jats:sub></jats:italic>). During testing sessions, incremental rowing test to exhaustion and swimming-specific performance test were introduced as exercise stimuli.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>At <jats:italic>COL<jats:sub>POST</jats:sub></jats:italic> visit the secretory IgA (SIgA) concentration in saliva was significantly higher at POST-EX and REC compared to REST (<jats:italic>p</jats:italic>&amp;lt;0.05). COL supplementation had no effect on blood IgA, IgE, IgD, IgG, and IgM concentrations. Furthermore, after COL supplementation decrease of hematocrit at REC (<jats:italic>p</jats:italic>&amp;lt;0.05) was revealed.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>12-week supplementation with 25 g<jats:sub>COL</jats:sub>·day<jats:sup>-1</jats:sup> in endurance-trained male athletes resulted in a favorable increase in post-exercise concentration of salivary SIgA. COL seems to be a potential stimulator of local immune defense after exercise-induced homeostasis disturbances. Nevertheless, the lack of effect on blood markers indicates the need for further research in the area of mechanisms underlying the effect of the supposed COL immunological capacity.</jats:p></jats:sec>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if5,7
dc.description.points140
dc.description.versionfinal_published
dc.description.volume15
dc.identifier.doi10.3389/fimmu.2024.1425785
dc.identifier.issn1664-3224
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/2036
dc.identifier.weblinkhttp://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1425785/full
dc.languageen
dc.relation.ispartofFrontiers in Immunology
dc.relation.pagesart. 1425785
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enimmunity
dc.subject.enimmunonutrition
dc.subject.ensports nutrition
dc.subject.energogenic support
dc.subject.enproteins
dc.subject.entriathlon
dc.titleThe effect of 12-week high-dose Colostrum Bovinum supplementation on immunological, hematological and biochemical markers in endurance athletes: a randomized crossover placebo-controlled study
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume15