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Morphomigrational description as a new approach connecting cell's migration with its morphology

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cris.virtual.author-orcid0000-0001-8734-724X
cris.virtual.author-orcid0000-0002-3344-1094
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dc.abstract.enThe examination of morphology and migration of cells plays substantial role in understanding the cellular behaviour, being described by plethora of quantitative parameters and models. These descriptions, however, treat cell migration and morphology as independent properties of temporal cell state, while not taking into account their strong interdependence in adherent cells. Here we present the new and simple mathematical parameter called signed morphomigrational angle (sMM angle) that links cell geometry with translocation of cell centroid, considering them as one morphomigrational behaviour. The sMM angle combined with pre-existing quantitative parameters enabled us to build a new tool called morphomigrational description, used to assign the numerical values to several cellular behaviours. Thus, the cellular activities that until now were characterized using verbal description or by complex mathematical models, are described here by a set of numbers. Our tool can be further used in automatic analysis of cell populations as well as in studies focused on cellular response to environmental directional signals.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Zoologii
dc.contributor.authorKołodziej, Tomasz
dc.contributor.authorMielnicka, Aleksandra
dc.contributor.authorDziob, Daniel
dc.contributor.authorChojnacka, Anna Katarzyna
dc.contributor.authorRawski, Mateusz
dc.contributor.authorMazurkiewicz, Jan
dc.contributor.authorRajfur, Zenon
dc.date.access2025-10-31
dc.date.accessioned2025-10-31T11:40:08Z
dc.date.available2025-10-31T11:40:08Z
dc.date.copyright2023-07-07
dc.date.issued2023
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>The examination of morphology and migration of cells plays substantial role in understanding the cellular behaviour, being described by plethora of quantitative parameters and models. These descriptions, however, treat cell migration and morphology as independent properties of temporal cell state, while not taking into account their strong interdependence in adherent cells. Here we present the new and simple mathematical parameter called <jats:italic>signed morphomigrational angle</jats:italic> (<jats:italic>sMM angle</jats:italic>) that links cell geometry with translocation of cell centroid, considering them as one morphomigrational behaviour. The sMM angle combined with pre-existing quantitative parameters enabled us to build a new tool called <jats:italic>morphomigrational description</jats:italic>, used to assign the numerical values to several cellular behaviours. Thus, the cellular activities that until now were characterized using verbal description or by complex mathematical models, are described here by a set of numbers. Our tool can be further used in automatic analysis of cell populations as well as in studies focused on cellular response to environmental directional signals.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,8
dc.description.points140
dc.description.versionfinal_published
dc.description.volume13
dc.identifier.doi10.1038/s41598-023-35827-9
dc.identifier.issn2045-2322
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5662
dc.identifier.weblinkhttps://www.nature.com/articles/s41598-023-35827-9
dc.languageen
dc.relation.ispartofScientific Reports
dc.relation.pagesart. 11006
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.titleMorphomigrational description as a new approach connecting cell's migration with its morphology
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume13