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Genetic risk score for gestational weight gain

cris.virtual.author-orcid0000-0002-4731-6243
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cris.virtual.author-orcid0000-0002-2045-0709
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cris.virtualsource.author-orcidd951fe7e-3886-48a5-8661-b05d0c844622
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cris.virtualsource.author-orcid20ac3fe1-f398-4ef7-ab0b-a6a20460f69f
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enGestational weight gain (GWG) involves health consequences for both mother and offspring. Genetic factors seem to play a role in the GWG trait. For small effect sizes of a single genetic polymorphism (SNP), a genetic risk score (GRS) summarizing risk-associated variation from multiple SNPs can serve as an effective approach to genetic association analysis. The aim of the study was to analyze the association between genetic risk score (GRS) and gestational weight gain (GWG). GWG was calculated for a total of 342 healthy Polish women of Caucasian origin, aged 19 to 45 years. The SNPs rs9939609 (FTO), rs6548238 (TMEM18), rs17782313 (MC4R), rs10938397 (GNPDA2), rs10913469 (SEC16B), rs1137101 (LEPR), rs7799039 (LEP), and rs5443 (GNB3) were genotyped using commercial TaqMan SNP assays. A simple genetic risk score was calculated into two ways: GRS1 based on the sum of risk alleles from each of the SNPs, while GRS2 based on the sum of risk alleles of FTO, LEPR, LEP, and GNB3. Positive association between GRS2 and GWG (β = 0.12, p = 0.029) was observed. Genetic risk variants of TMEM18 (p = 0.006, OR = 2.6) and GNB3 (p < 0.001, OR = 3.3) are more frequent in women with increased GWG, but a risk variant of GNPDA2 (p < 0.001, OR = 2.7) is more frequent in women with adequate GWG, and a risk variant of LEPR (p = 0.011, OR = 3.1) in women with decreased GWG. GRS2 and genetic variants of TMEM18, GNB3, GNPDA2, and LEPR are associated with weight gain during pregnancy.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorMikołajczyk-Stecyna, Joanna
dc.contributor.authorZuk, Ewelina
dc.contributor.authorSeremak-Mrozikiewicz, Agnieszka
dc.contributor.authorKurzawińska, Grażyna
dc.contributor.authorWolski, Hubert
dc.contributor.authorDrews, Krzysztof
dc.contributor.authorChmurzyńska, Agata
dc.date.accessioned2025-08-12T13:06:00Z
dc.date.available2025-08-12T13:06:00Z
dc.date.issued2024
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if1,9
dc.description.numberMarch 2024
dc.description.points70
dc.description.volume294
dc.identifier.doi10.1016/j.ejogrb.2023.12.031
dc.identifier.eissn1872-7654
dc.identifier.issn0301-2115
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4160
dc.languageen
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
dc.relation.pages20-27
dc.rightsClosedAccess
dc.sciencecloudsend
dc.subject.enbody mass
dc.subject.engenetic risk score
dc.subject.engestational weight gain
dc.subject.enpregnancy
dc.subject.ensingle nucleotide polymorphism
dc.titleGenetic risk score for gestational weight gain
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume294