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THC-Reduced Cannabis sativa L.—How Does the Solvent Determine the Bioavailability of Cannabinoids Given Orally?

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dc.abstract.enThe bioavailability levels of cannabidiol (CBD) and tetrahydrocannabinol (THC) determine their pharmacological effects. Therefore, for medical purposes, it is essential to obtain extracts containing the lowest possible content of the psychogenic component THC. In our extract, the CBD/THC ratio was 16:1, which is a high level compared to available medical preparations, where it is, on average, 1:1. This study assessed the bioavailability and stability of CBD and THC derived from Cannabis sativa L. with reduced THC content. The extract was orally administered (30 mg/kg) in two solvents, Rapae oleum and Cremophor, to forty-eight Wistar rats. The whole-blood and brain concentrations of CBD and THC were measured using liquid chromatography coupled with mass spectrometry detection. Much higher concentrations of CBD than THC were observed for both solvents in the whole-blood and brain after oral administration of the Cannabis sativa extract with a decreased THC content. The total bioavailability of both CBD and THC was higher for Rapae oleum compared to Cremophor. Some of the CBD was converted into THC in the body, which should be considered when using Cannabis sativa for medical purposes. The THC-reduced hemp extract in this study is a promising candidate for medical applications.
dc.affiliationWydział Rolnictwa, Ogrodnictwa i Bioinżynierii
dc.affiliation.instituteKatedra Biochemii i Biotechnologii
dc.contributor.authorBartkowiak-Wieczorek, Joanna
dc.contributor.authorMądry, Edyta
dc.contributor.authorKsiążkiewicz, Michał
dc.contributor.authorWinkler-Galicki, Jakub
dc.contributor.authorSzalata, Milena
dc.contributor.authorSzalata, Marlena
dc.contributor.authorJiménez, Ulises Elizalde
dc.contributor.authorWielgus, Karolina
dc.contributor.authorGrześkowiak, Edmund
dc.contributor.authorSłomski, Ryszard
dc.contributor.authorBienert, Agnieszka
dc.date.access2025-08-18
dc.date.accessioned2025-10-28T12:43:03Z
dc.date.available2025-10-28T12:43:03Z
dc.date.copyright2023-06-06
dc.date.issued2023
dc.description.abstract<jats:p>The bioavailability levels of cannabidiol (CBD) and tetrahydrocannabinol (THC) determine their pharmacological effects. Therefore, for medical purposes, it is essential to obtain extracts containing the lowest possible content of the psychogenic component THC. In our extract, the CBD/THC ratio was 16:1, which is a high level compared to available medical preparations, where it is, on average, 1:1. This study assessed the bioavailability and stability of CBD and THC derived from Cannabis sativa L. with reduced THC content. The extract was orally administered (30 mg/kg) in two solvents, Rapae oleum and Cremophor, to forty-eight Wistar rats. The whole-blood and brain concentrations of CBD and THC were measured using liquid chromatography coupled with mass spectrometry detection. Much higher concentrations of CBD than THC were observed for both solvents in the whole-blood and brain after oral administration of the Cannabis sativa extract with a decreased THC content. The total bioavailability of both CBD and THC was higher for Rapae oleum compared to Cremophor. Some of the CBD was converted into THC in the body, which should be considered when using Cannabis sativa for medical purposes. The THC-reduced hemp extract in this study is a promising candidate for medical applications.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,8
dc.description.number12
dc.description.points140
dc.description.versionfinal_published
dc.description.volume15
dc.identifier.doi10.3390/nu15122646
dc.identifier.issn2072-6643
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5550
dc.identifier.weblinkhttps://www.mdpi.com/2072-6643/15/12/2646
dc.languageen
dc.relation.ispartofNutrients
dc.relation.pagesart. 2646
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enendocannabinoid system
dc.subject.encannabidiol (CBD)
dc.subject.entetrahydrocannabinol (THC)
dc.subject.enbioavailability
dc.subject.enpharmacokinetics
dc.titleTHC-Reduced Cannabis sativa L.—How Does the Solvent Determine the Bioavailability of Cannabinoids Given Orally?
dc.title.volumeThis article belongs to the Special Issue Natural Products and Health
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue12
oaire.citation.volume15