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Effects of daily probiotic supplementation with Lactobacillus acidophilus on calcium status, bone metabolism biomarkers, and bone mineral density in postmenopausal women: a controlled and randomized clinical study

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cris.virtual.author-orcid0000-0002-6085-4855
cris.virtual.author-orcid0000-0002-4173-5965
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cris.virtual.author-orcid0000-0002-0937-8427
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cris.virtualsource.author-orcid20258df6-7058-4f33-9a7a-ab392117b6f3
cris.virtualsource.author-orcidc8f75a2c-3403-4f93-aa73-6cf0ae8b543d
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cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
dc.abstract.enBackground: Menopause poses significant health risks for women, particularly an increased vulnerability to fractures associated with osteoporosis. Dietary interventions have emerged as promising strategies, focusing on mitigating the risk of osteoporosis rather than solely addressing the established disease. This 12-week randomized controlled trial aimed to analyze the effects of consuming Lactobacillus acidophilus probiotics on calcium levels, biomarkers of bone metabolism, and bone mineral density (BMD) profiles in postmenopausal women. Methods: Fifty-five participants were randomly assigned to receive either a placebo (n = 25) or the probiotic L. acidophilus UALa-01TM (n = 30) daily via oral intervention. Throughout the study, evaluations included body composition, blood biochemical parameters, serum calcium levels, and biomarkers of bone metabolism. Additionally, Dual-energy X-ray absorptiometry was used to measure BMD profiles. Results: The findings delineated that the probiotic group experienced a decrease in serum calcium levels compared to their initial levels. However, hair calcium levels and biomarkers related to bone metabolism showed no notable changes within this group. Consumption of probiotic L. acidophilus also seemed to prevent fluctuations in bone turnover markers. Moreover, there were no significant alterations in BMD levels at the lumbar spine, left femur, and total body in the probiotic group. Additionally, probiotic intake led to favorable outcomes by significantly reducing both body fat and visceral fat during the intervention period. Conversely, an adverse effect of consuming probiotic L. acidophilus was observed with a significant increase in glucose concentration Conclusion: In conclusion, the consumption of L. acidophilus probiotics daily for 12 weeks among postmenopausal women does not affect the profile of BMD, but it may help in stabilizing bone turnover. It is important to note that most measured parameters were within the normal range for this population. However, it is worth noting that 3 months of probiotic supplementation could potentially disrupt calcium and glucose status in postmenopausal women.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorHarahap, Iskandar Azmy
dc.contributor.authorMoszak, Małgorzata
dc.contributor.authorCzłapka-Matyasik, Magdalena
dc.contributor.authorSkrypnik, Katarzyna
dc.contributor.authorBogdański, Paweł
dc.contributor.authorSuliburska, Joanna
dc.date.access2024-10-03
dc.date.accessioned2024-10-03T09:34:41Z
dc.date.available2024-10-03T09:34:41Z
dc.date.copyright2024-07-01
dc.date.issued2024
dc.description.abstract<jats:sec><jats:title>Background</jats:title><jats:p>Menopause poses significant health risks for women, particularly an increased vulnerability to fractures associated with osteoporosis. Dietary interventions have emerged as promising strategies, focusing on mitigating the risk of osteoporosis rather than solely addressing the established disease. This 12-week randomized controlled trial aimed to analyze the effects of consuming <jats:italic>Lactobacillus acidophilus</jats:italic> probiotics on calcium levels, biomarkers of bone metabolism, and bone mineral density (BMD) profiles in postmenopausal women.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Fifty-five participants were randomly assigned to receive either a placebo (<jats:italic>n</jats:italic> = 25) or the probiotic <jats:italic>L. acidophilus</jats:italic> UALa-01™ (<jats:italic>n</jats:italic> = 30) daily via oral intervention. Throughout the study, evaluations included body composition, blood biochemical parameters, serum calcium levels, and biomarkers of bone metabolism. Additionally, Dual-energy X-ray absorptiometry was used to measure BMD profiles.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The findings delineated that the probiotic group experienced a decrease in serum calcium levels compared to their initial levels. However, hair calcium levels and biomarkers related to bone metabolism showed no notable changes within this group. Consumption of probiotic <jats:italic>L. acidophilus</jats:italic> also seemed to prevent fluctuations in bone turnover markers. Moreover, there were no significant alterations in BMD levels at the lumbar spine, left femur, and total body in the probiotic group. Additionally, probiotic intake led to favorable outcomes by significantly reducing both body fat and visceral fat during the intervention period. Conversely, an adverse effect of consuming probiotic <jats:italic>L. acidophilus</jats:italic> was observed with a significant increase in glucose concentration.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In conclusion, the consumption of <jats:italic>L. acidophilus</jats:italic> probiotics daily for 12 weeks among postmenopausal women does not affect the profile of BMD, but it may help in stabilizing bone turnover. It is important to note that most measured parameters were within the normal range for this population. However, it is worth noting that 3 months of probiotic supplementation could potentially disrupt calcium and glucose status in postmenopausal women.</jats:p></jats:sec>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0.00
dc.description.if4,0
dc.description.points70
dc.description.reviewreview
dc.description.versionfinal_published
dc.description.volume11
dc.identifier.doi10.3389/fnut.2024.1401920
dc.identifier.issn2296-861X
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/1766
dc.identifier.weblinkhttps://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1401920/full
dc.languageen
dc.relation.ispartofFrontiers in Nutrition
dc.relation.pagesart. 1401920
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enprobiotic
dc.subject.encalcium status
dc.subject.enbone health
dc.subject.enDXA (dual-energy X-ray absorptiometry)
dc.subject.enmenopause
dc.titleEffects of daily probiotic supplementation with Lactobacillus acidophilus on calcium status, bone metabolism biomarkers, and bone mineral density in postmenopausal women: a controlled and randomized clinical study
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume11