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The Effect of Glutamine as Feed Additive on Selected Parameters of the Nonspecific Immune Response in Pigs

cris.lastimport.scopus2025-10-23T06:56:57Z
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dc.abstract.enThe use of feed additives containing glutamine can influence the growth and development of piglets during the weaning period. The aim of this study was to determine the effect of feed supplementation with 0.5% L-glutamine on selected parameters of the nonspecific immune response of pigs. The research was carried out on 60 pigs (Polish Large White × Polish Landrace), from 28 days of age to slaughter. The obtained results showed an increased percentage of phagocytic cells (monocytes and granulocytes) and oxygen blast cells in pigs between 28 and 70 days of age, proving that non-specific immune mechanisms were stimulated, which contributed to the improvement of the processes of antigen elimination from the body. The increase in the percentage of cells expressing SWC3, CD11b/CD18+, CD14+ and CD14+CD16+ molecules on granulocytes and monocytes during this period resulted in the enhancement of the host defense mechanisms by stimulating phagocytosis and enhancing the mechanisms of a non-specific immune response. The high concentration of TNF-α and IL-1β as well as Il-10 in the experimental group indicates the cellular phenotype of the Th1-type response, and the maintenance of the immune balance between the pro-inflammatory and anti-inflammatory responses and ensuring the homeostasis of the organism
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Hodowli Zwierząt i Oceny Surowców
dc.contributor.authorJarosz, Łukasz S.
dc.contributor.authorTomaszewska, Ewa
dc.contributor.authorMarek, Agnieszka
dc.contributor.authorHejdysz, Marcin
dc.contributor.authorBurmańczuk, Artur
dc.contributor.authorCiszewski, Artur
dc.contributor.authorNowaczewski, Sebastian
dc.contributor.authorGrądzki, Zbigniew
dc.contributor.authorBatorski, Maciej
dc.contributor.authorŚwiątkiewicz, Małgorzata
dc.contributor.authorRysiak, Anna
dc.date.access2025-08-27
dc.date.accessioned2025-08-27T11:48:40Z
dc.date.available2025-08-27T11:48:40Z
dc.date.copyright2023-04-21
dc.date.issued2023
dc.description.abstract<jats:p>The use of feed additives containing glutamine can influence the growth and development of piglets during the weaning period. The aim of this study was to determine the effect of feed supplementation with 0.5% L-glutamine on selected parameters of the nonspecific immune response of pigs. The research was carried out on 60 pigs (Polish Large White × Polish Landrace), from 28 days of age to slaughter. The obtained results showed an increased percentage of phagocytic cells (monocytes and granulocytes) and oxygen blast cells in pigs between 28 and 70 days of age, proving that non-specific immune mechanisms were stimulated, which contributed to the improvement of the processes of antigen elimination from the body. The increase in the percentage of cells expressing SWC3, CD11b/CD18+, CD14+ and CD14+CD16+ molecules on granulocytes and monocytes during this period resulted in the enhancement of the host defense mechanisms by stimulating phagocytosis and enhancing the mechanisms of a non-specific immune response. The high concentration of TNF-α and IL-1β as well as Il-10 in the experimental group indicates the cellular phenotype of the Th1-type response, and the maintenance of the immune balance between the pro-inflammatory and anti-inflammatory responses and ensuring the homeostasis of the organism.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,3
dc.description.number4
dc.description.points140
dc.description.versionfinal_published
dc.description.volume13
dc.identifier.doi10.3390/agriculture13040912
dc.identifier.issn2077-0472
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4444
dc.identifier.weblinkhttp://www.mdpi.com/2077-0472/13/4/912
dc.languageen
dc.relation.ispartofAgriculture (Switzerland)
dc.relation.pagesart. 912
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enpig
dc.subject.englutamine
dc.subject.enphagocytosis
dc.subject.ennonspecific immune response
dc.subject.enflow cytometry
dc.titleThe Effect of Glutamine as Feed Additive on Selected Parameters of the Nonspecific Immune Response in Pigs
dc.title.volumeSpecial Issue Effects of Nutrition Quality on the Health, Productivity, and Performance of Livestock
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.volume13