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Antibody response and abomasal histopathology of lambs with haemonchosis during supplementation with medicinal plants and organic selenium

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dc.abstract.enWe evaluated the effects of dietary supplementation with medicinal plants (Herbmix) or organic selenium (Selplex) on the immune responses and histopathology of lambs infected with Haemonchus contortus. Twenty-seven lambs were infected and reinfected with approximately 11,000 third-stage larvae of H. contortus during the experiment (on days 0, 49 and 77). Lambs were divided into two supplemented experimental groups (Herbmix and Selplex) and unsupplemented group (Control). The abomasal worm counts at necropsy on day 119 were lower for Herbmix (4230) and Selplex group (3220) than to the Control (6613) which resulted in 51.3% and 36.0% of reduction, respectively. The mean length of adult female worms was in the order Control > Herbmix > Selplex (2.1, 2.08, and 2.01 cm, respectively). The specific IgG response against adults was significantly affected by time (P < 0.001). Serum-specific and total mucus levels of IgA in the Herbmix group were highest on day 15. Mean levels of serum IgM against adults were influenced by treatment (P = 0.048) and time (P < 0.001). The Herbmix group had strong local inflammation in the abomasal tissue, with the formation of lymphoid aggregates and the infiltration of immune cells, but the tissues of the Selplex group had higher numbers of eosinophils, globule leukocytes, and plasma cells. The lymph nodes of each animal had reactive follicular hyperplasia due to the infection. Dietary nutritional supplementation with a mixture of medicinal plants or organic selenium could improve local immune responses and thus enhance the resistance of animals to this parasitic infection.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Nauk Przedklinicznych i Chorób Zakaźnych
dc.affiliation.instituteKatedra Żywienia Zwierząt
dc.contributor.authorBatťányi, Dominika
dc.contributor.authorPetrič, Daniel
dc.contributor.authorBabják, Michal
dc.contributor.authorDvorožňáková, Emília
dc.contributor.authorŁukomska, Anna
dc.contributor.authorCieślak, Adam
dc.contributor.authorVárady, Marián
dc.contributor.authorVáradyová, Zora
dc.date.access2025-11-07
dc.date.accessioned2025-11-07T08:40:52Z
dc.date.available2025-11-07T08:40:52Z
dc.date.copyright2023-02-10
dc.date.issued2023
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if1,9
dc.description.numberMarch 2023
dc.description.points20
dc.description.versionfinal_published
dc.description.volume19
dc.identifier.doi10.1016/j.vas.2023.100290
dc.identifier.issn2451-943X
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5798
dc.identifier.weblinkhttp://www.sciencedirect.com/science/article/pii/S2451943X23000078
dc.languageen
dc.relation.ispartofVeterinary and Animal Science
dc.relation.pagesart. 100290
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enantibody responses
dc.subject.enHaemonchus contortus
dc.subject.enhistopathology
dc.subject.enmedicinal plants
dc.subject.enresistance
dc.subject.enselenium
dc.titleAntibody response and abomasal histopathology of lambs with haemonchosis during supplementation with medicinal plants and organic selenium
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume19