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A low glycemic index, energy-restricted diet but not Lactobacillus rhamnosus supplementation changes fecal short-chain fatty acid and serum lipid concentrations in women with overweight or obesity and polycystic ovary syndrome

cris.virtual.author-orcid0000-0003-1996-5198
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid1ccb8edd-cf11-49a4-bd1c-af5fd753fdc7
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enOBJECTIVE: To evaluate if changes in fecal short-chain fatty acids (SCFA) content with an energy-restricted diet and with/without 12 × 109 CFU/day of Lactobacillus rhamnosus supplementation affect the abundance of selected gut bacteria and lipid profile in overweight and obese women with PCOS. PATIENTS AND METHODS: This randomized controlled trial involved 40 overweight and obese women with a mean age of 28.8 ± 4.8 years diagnosed with PCOS. The subjects were randomly assigned to an energy-restricted diet group (D group; n = 21) or energy-restricted diet + Lactobacillus rhamnosus supplementation group (DP group; n=19). SCFA, selected gut bacteria (Akkermansia muciniphila, Bifidobacterium longum, and Faecalibacterium prausnitzii) abundance, lipid profile and anthropometric parameters were evaluated at baseline and after twenty weeks of intervention. RESULTS: The energy-restricted diet significantly reduced body weight, BMI, fat mass, acetic and butyric acids, and improved the lipid profile (total cholesterol, low-density lipoprotein cholesterol, and triglycerides) of both groups. Changes in the molar ratio of SCFA towards the correct ratio were also observed. All the results were independent of Lactobacillus rhamnosus supplementation, with no significant differences between the two groups. CONCLUSIONS: Twenty weeks of probiotic supplementation has no additional beneficial effects on selected gut bacteria abundance, SCFA levels, or lipid profile beyond the effect of an energy-restricted diet in overweight and obese women with PCOS.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorŁagowska, Karolina
dc.contributor.authorDrzymała-Czyż, S.
dc.date.access2026-02-11
dc.date.accessioned2026-02-27T11:55:17Z
dc.date.available2026-02-27T11:55:17Z
dc.date.copyright2022-02-14
dc.date.issued2022
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,3
dc.description.number3
dc.description.points70
dc.description.versionfinal_published
dc.description.volume26
dc.identifier.doi10.26355/eurrev_202202_28001
dc.identifier.eissn2284-0729
dc.identifier.issn1128-3602
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7528
dc.identifier.weblinkhttps://www.europeanreview.org/article/28001
dc.languageen
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciences
dc.relation.pages917-926
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enshort chain fatty acids
dc.subject.enobesity
dc.subject.enlipids
dc.subject.endiet
dc.titleA low glycemic index, energy-restricted diet but not Lactobacillus rhamnosus supplementation changes fecal short-chain fatty acid and serum lipid concentrations in women with overweight or obesity and polycystic ovary syndrome
dc.typeJournalArticle
dspace.entity.typePublication