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Endocrine Effect of Some Mycotoxins on Humans: A Clinical Review of the Ways to Mitigate the Action of Mycotoxins

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cris.virtual.author-orcid0000-0003-4961-2959
cris.virtual.author-orcid0000-0003-4057-7333
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cris.virtualsource.author-orcidd262a047-0e71-4e00-b46b-5167dd661a3d
cris.virtualsource.author-orcidedaa3f24-c687-4516-93a8-b178493c02f0
dc.abstract.enFungi such as Aspergillus spp. and Fusarium spp., which are commonly found in the environment, pose a serious global health problem. This study aims to present the results of epidemiological studies, including clinical cases, on the relationship between human exposure to some mycotoxins, especially zearalenone and aflatoxin, and the occurrence of reproductive disorders. In addition, examples of methods to reduce human exposure to mycotoxins are presented. In March 2023, various databases (PubMed, Google Scholar, EMBASE and Web of Science) were systematically searched using Google Chrome to identify studies evaluating the association between exposure to mycotoxins and the occurrence of complications related to impaired fertility or cancer incidence. The analysed data indicate that exposure to the evaluated mycotoxins is widespread and correlates strongly with precocious puberty, reduced fertility and increased cancer incidence in women and men worldwide. There is evidence to suggest that exposure to the Aspergillus mycotoxin aflatoxin (AF) during pregnancy can impair intrauterine foetal growth, promote neonatal jaundice and cause perinatal death and preterm birth. In contrast, exposure to the Fusarium mycotoxin zearalenone (ZEA) leads to precocious sexual development, infertility, the development of malformations and the development of breast cancer. Unfortunately, the development of methods (biological, chemical or physical) to completely eliminate exposure to mycotoxins has limited practical application. The threat to human health from mycotoxins is real and further research is needed to improve our knowledge and specific public health interventions.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Nauk Przedklinicznych i Chorób Zakaźnych
dc.contributor.authorKościelecka, Klaudia
dc.contributor.authorKuć, Aleksandra
dc.contributor.authorKubik-Machura, Daria
dc.contributor.authorMęcik-Kronenberg, Tomasz
dc.contributor.authorWłodarek, Jan
dc.contributor.authorRadko, Lidia
dc.date.access2025-11-06
dc.date.accessioned2025-11-06T12:16:27Z
dc.date.available2025-11-06T12:16:27Z
dc.date.copyright2023-08-23
dc.date.issued2023
dc.description.abstract<jats:p>Fungi such as Aspergillus spp. and Fusarium spp., which are commonly found in the environment, pose a serious global health problem. This study aims to present the results of epidemiological studies, including clinical cases, on the relationship between human exposure to some mycotoxins, especially zearalenone and aflatoxin, and the occurrence of reproductive disorders. In addition, examples of methods to reduce human exposure to mycotoxins are presented. In March 2023, various databases (PubMed, Google Scholar, EMBASE and Web of Science) were systematically searched using Google Chrome to identify studies evaluating the association between exposure to mycotoxins and the occurrence of complications related to impaired fertility or cancer incidence. The analysed data indicate that exposure to the evaluated mycotoxins is widespread and correlates strongly with precocious puberty, reduced fertility and increased cancer incidence in women and men worldwide. There is evidence to suggest that exposure to the Aspergillus mycotoxin aflatoxin (AF) during pregnancy can impair intrauterine foetal growth, promote neonatal jaundice and cause perinatal death and preterm birth. In contrast, exposure to the Fusarium mycotoxin zearalenone (ZEA) leads to precocious sexual development, infertility, the development of malformations and the development of breast cancer. Unfortunately, the development of methods (biological, chemical or physical) to completely eliminate exposure to mycotoxins has limited practical application. The threat to human health from mycotoxins is real and further research is needed to improve our knowledge and specific public health interventions.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,9
dc.description.number9
dc.description.points140
dc.description.versionfinal_published
dc.description.volume15
dc.identifier.doi10.3390/toxins15090515
dc.identifier.issn2072-6651
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5781
dc.identifier.weblinkhttps://www.mdpi.com/2072-6651/15/9/515
dc.languageen
dc.relation.ispartofToxins
dc.relation.pagesart. 515
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enmycotoxins
dc.subject.enaflatoxin
dc.subject.enzearalenone
dc.subject.enhuman
dc.subject.enreproductive interference
dc.subject.enrisk assessment
dc.subject.enstrategies reduction exposure
dc.subtypeReviewArticle
dc.titleEndocrine Effect of Some Mycotoxins on Humans: A Clinical Review of the Ways to Mitigate the Action of Mycotoxins
dc.title.volumeSpecial Issue Mitigation and Detoxification Strategies of Mycotoxins
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue9
oaire.citation.volume15