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Leptin–VEGF crosstalk in excess body mass and related disorders: A systematic review

cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid0000-0002-4173-5965
cris.virtual.author-orcid0000-0002-0937-8427
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcidc8f75a2c-3403-4f93-aa73-6cf0ae8b543d
cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enBy 2030, it is expected that a billion people will have suffer from obesity. Adipose tis-sue synthesizes leptin, an adipokine that affects cardiovascular risk. Leptin intensifiesthe synthesis of vascular endothelial growth factor (VEGF). Our study reviews recentreports on leptin–VEGF crosstalk in obesity and related disorders. PubMed, Web ofScience, Scopus, and Google Scholar were searched. One hundred and one articlesinvolving human, animal, and in vitro research were included. In vitro studies show thecrucial role of interaction between endothelial cells and adipocytes and hypoxia as a fac-tor that intensifies leptin's effects on VEGF. Leptin–VEGF crosstalk promotes the pro-gression of cancer. The animal research reveal that a high-fat diet enhances leptin andVEGF crosstalk. Genetic and epigenetic mechanisms and procreator-offspring program-ming may be involved in leptin–VEGF crosstalk. Some female-specific characteristics ofleptin–VEGF relation in obesity were observed. The human studies have shown thatincreased leptin and VEGF synthesis and leptin–VEGF crosstalk are factors linking obe-sity with elevated cardiovascular risk. The studies of the last 10 years documented arange of significant aspects of leptin–VEGF crosstalk specific for obesity and related dis-orders, shedding new light on the link between obesity and increased cardiovascular risk.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorSkrypnik, Damian
dc.contributor.authorSkrypnik, Katarzyna
dc.contributor.authorSuliburska, Joanna
dc.contributor.authorBogdański, Paweł
dc.date.accessioned2025-10-28T13:22:56Z
dc.date.available2025-10-28T13:22:56Z
dc.date.issued2023
dc.description.abstract<jats:title>Summary</jats:title><jats:p>By 2030, it is expected that a billion people will have suffer from obesity. Adipose tissue synthesizes leptin, an adipokine that affects cardiovascular risk. Leptin intensifies the synthesis of vascular endothelial growth factor (VEGF). Our study reviews recent reports on leptin–VEGF crosstalk in obesity and related disorders. PubMed, Web of Science, Scopus, and Google Scholar were searched. One hundred and one articles involving human, animal, and in vitro research were included. <jats:bold>In vitro studies</jats:bold> show the crucial role of interaction between endothelial cells and adipocytes and hypoxia as a factor that intensifies leptin's effects on VEGF. Leptin–VEGF crosstalk promotes the progression of cancer. The <jats:bold>animal research</jats:bold> reveal that a high‐fat diet enhances leptin and VEGF crosstalk. Genetic and epigenetic mechanisms and procreator‐offspring programming may be involved in leptin–VEGF crosstalk. Some female‐specific characteristics of leptin–VEGF relation in obesity were observed. The <jats:bold>human studies</jats:bold> have shown that increased leptin and VEGF synthesis and leptin–VEGF crosstalk are factors linking obesity with elevated cardiovascular risk. The studies of the last 10 years documented a range of significant aspects of leptin–VEGF crosstalk specific for obesity and related disorders, shedding new light on the link between obesity and increased cardiovascular risk.</jats:p>
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if8,0
dc.description.number8
dc.description.points200
dc.description.volume24
dc.identifier.doi10.1111/obr.13575
dc.identifier.eissn1467-789X
dc.identifier.issn1467-7881
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5560
dc.identifier.weblinkhttps://onlinelibrary.wiley.com/doi/10.1111/obr.13575
dc.languageen
dc.relation.ispartofObesity Reviews
dc.relation.pagese13575
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enleptin
dc.subject.enobesity
dc.subject.envascular endothelial growth factor
dc.subject.enVEGF
dc.subtypeReviewArticle
dc.titleLeptin–VEGF crosstalk in excess body mass and related disorders: A systematic review
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue8
oaire.citation.volume24