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Experimental Capacity of Human Fecal Microbiota to Degrade Fiber and Produce Short-Chain Fatty Acids Is Associated with Diet Quality and Anthropometric Parameters

cris.virtual.author-orcid0000-0002-7402-1328
cris.virtual.author-orcid0000-0003-4234-7881
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cris.virtual.author-orcid0000-0001-8417-2245
cris.virtualsource.author-orcid59851afa-3d5d-435f-95ee-4130cbd454a0
cris.virtualsource.author-orcid4ee23ba3-eef2-455b-bf2c-1c2dcfc4df21
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cris.virtualsource.author-orcidedf63522-bb89-4788-a8d3-9c3f3858875b
dc.abstract.enBackground Short-chain fatty acids (SCFAs) are considered beneficial to human health. The associations between bacterial capacity to produce SCFAs, diet, and health are not fully understood. Objective We aimed to evaluate the capacity of human fecal microbiota to produce SCFAs and to metabolize soluble and insoluble fiber and to study its associations with human diet, anthropometric parameters, and carbohydrate and lipid metabolism. Methods A cross-sectional study was carried out with 200 adult participants. Diet was evaluated using food records. Capacity to produce acetate, butyrate, and propionate and to degrade soluble fiber were assessed in an ex vivo experiment where fecal samples were inoculated in a pectin-containing broth. Fecal β-glucosidase activity was measured to assess potential to degrade insoluble fiber. Results The main dietary determinants of high capacity to metabolize fiber were high intake of vegetables, fruits, nuts, and seeds. After adjusting analyses for confounders, glucose and lipid parameters were not significantly associated with any of the studied microbial capacities, but the capacity to produce propionic acid was significantly associated with hip circumference (β = −0.018, P = 0.044), which was seen especially in people eating healthy. Conclusions We confirmed that high intake of fiber-rich products is positively associated with the capacity of fecal microbiota to degrade soluble and insoluble dietary fiber and that people eating healthy food might benefit from enhanced microbial capacity to produce propionic acid.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.affiliation.instituteKatedra Technologii Żywności Pochodzenia Roślinnego
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.contributor.authorMalinowska, Anna Maria
dc.contributor.authorMajcher, Małgorzata Anna
dc.contributor.authorHooiveld, Guido JEJ.
dc.contributor.authorPrzydatek, Hanna
dc.contributor.authorSzaban, Marta
dc.contributor.authorKurowiecka, Agata
dc.contributor.authorSchmidt, Marcin
dc.date.access2025-07-04
dc.date.accessioned2025-10-27T11:12:41Z
dc.date.available2025-10-27T11:12:41Z
dc.date.copyright2023-08-10
dc.date.issued2023
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,7
dc.description.number10 (October 2023)
dc.description.points140
dc.description.versionfinal_published
dc.description.volume153
dc.identifier.doi10.1016/j.tjnut.2023.08.007
dc.identifier.eissn1541-6100
dc.identifier.issn0022-3166
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5473
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S0022316623725315?
dc.languageen
dc.relation.ispartofJournal of Nutrition
dc.relation.pages2827-2841
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOTHER
dc.subject.endiet quality
dc.subject.engut microbiota
dc.subject.enfiber
dc.subject.enshort-chain fatty acids
dc.subject.enobesity
dc.titleExperimental Capacity of Human Fecal Microbiota to Degrade Fiber and Produce Short-Chain Fatty Acids Is Associated with Diet Quality and Anthropometric Parameters
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue10
oaire.citation.volume153