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Genoprotective effect of cornelian cherry (Cornus mas L.) phytochemicals, electrochemical and ab initio interaction study

cris.virtual.author-orcid0000-0002-9498-819X
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid0000-0002-9011-8592
cris.virtual.author-orcid0000-0003-2834-0405
cris.virtualsource.author-orcidd9f431b5-a0b9-488d-959c-edc054dfb309
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid5a92c57a-50a8-4d53-a17d-17ad767a350e
cris.virtualsource.author-orcida13de6c4-588c-42db-93b8-c78ea84734b3
dc.abstract.enCornelian cherry (Cornus mas L.) has broad and multidimensional potential in preventing civilisational diseases. Part of these diseases results from DNA oxidative mutations. Thus, the paper aimed to predict how phenolics present in C. mas may interact with dsDNA in ab initio experiment and to check the effect of different cornelian cherry extracts on DNA structure and DNA oxidation. A special research model was designed using biosensor with a carbonpaste electrode. We resulted in various effects observed for phenolics and the extracts. Flavonoids, but of vitexin interacted with declining energy of the DNA models and liability of DNA oxidation. However, for 8-oxoguaniosine the trend was the opposite. Among the evaluated extracts, water-ethanolic extracts caused decline in adenine and guanine signals after dsDNA exposition on the extract. Principal component analysis showed that alcoholic extracts of cv. Szafer and SÅ‚owianin, which were rich in apigenin and kaempferol exhibit mild genoprotective effect.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliationWydział Leśny i Technologii Drewna
dc.affiliation.instituteKatedra Technologii Gastronomicznej i Żywności Funkcjonalnej
dc.affiliation.instituteKatedra Chemii
dc.contributor.authorSzczepaniak, Oskar
dc.contributor.authorLigaj, Marta
dc.contributor.authorStuper-Szablewska, Kinga
dc.contributor.authorKobus-Cisowska, Joanna
dc.date.access2026-01-30
dc.date.accessioned2026-02-10T09:53:30Z
dc.date.available2026-02-10T09:53:30Z
dc.date.copyright2022-06-02
dc.date.issued2022
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if7,5
dc.description.numberAugust 2022
dc.description.points100
dc.description.versionfinal_published
dc.description.volume152
dc.identifier.doi10.1016/j.biopha.2022.113216
dc.identifier.issn0753-3322
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7280
dc.identifier.weblinkwww.sciencedirect.com/science/article/pii/S0753332222006059?via%3Dihub
dc.languageen
dc.relation.ispartofBiomedicine and Pharmacotherapy
dc.relation.pagesart. 113216
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enHartree-Fock
dc.subject.enDNA interaction
dc.subject.enDNA oxidation
dc.subject.enpolyphenols
dc.titleGenoprotective effect of cornelian cherry (Cornus mas L.) phytochemicals, electrochemical and ab initio interaction study
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume152