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Copper oxide nanoparticles-mediated <i>Heliotropium bacciferum</i> leaf extract: Antifungal activity and molecular docking assays against strawberry pathogens

cris.lastimport.scopus2025-10-23T06:59:56Z
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dc.abstract.enIn the current study, Heliotropium bacciferum leaf extract was used to biosynthesize copper oxide nanoparticles (CuO-NPs). Various analytical techniques were used to characterize the produced CuO-NPs. Transmission electron microscope investigation indicated well-distributed spherical particles in various development phases. The particles’ diameters ranged from 22.15 to 37.01 nm, with an average of 24.8 ± 6.1 nm. Energy dispersive X-ray examination confirmed the presence of nanoscale Cu ions at a high concentration, as seen by the strong signal peak at 1 keV. Fourier transform infrared spectrum revealed various functional groups on the green-produced CuO-NPs, as evidenced by multiple absorption beaks. The bands found at 3,195 and 2,916 cm−1 revealed that phenolic and flavonoid compounds’ alcohols and alkanes were stretching C–H. Also, a band at 1,034 cm−1 is typically attributed to CuO production. CuO-NPs exhibited significant bioactivity against isolated and molecularly identified fungal strains, including Rhizoctonia solani (OR116528), Fusarium oxysporum (OR116508), and Botrytis cinerea (OR116491). Remarkably, the highest inhibition percentages were recorded at 100 µg/mL, with values 81.48, 71.11, and 50.74% for R. solani, F. oxysporum, and B. cinerea, respectively. Molecular docking interactions revealed that the highest binding affinity of CuO-NPs was −5.1 for the oxidoreductase of B. cinerea and −5.2 and −5.4 for the chitin synthase of R. solani and F. oxysporum, respectively. Consequentially, the biosynthesized CuO-NPs could be employed as antifungal biocontrol agents, as well as using H. bacciferum leaf extract for the synthesis of nanoparticles for various sustainable agricultural applications.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Technologii Żywności Pochodzenia Roślinnego
dc.contributor.authorHamdy, Esraa
dc.contributor.authorEl-Gendi, Hamada
dc.contributor.authorAl-Askar, Abdulaziz
dc.contributor.authorEl-Far, Ali
dc.contributor.authorKowalczewski, Przemysław Łukasz
dc.contributor.authorBehiry, Said
dc.contributor.authorAbdelkhalek, Ahmed
dc.date.access2025-05-12
dc.date.accessioned2025-08-14T06:10:38Z
dc.date.available2025-08-14T06:10:38Z
dc.date.copyright2024-05-06
dc.date.issued2024
dc.description.abstract<jats:title>Abstract</jats:title> <jats:p>In the current study, <jats:italic>Heliotropium bacciferum</jats:italic> leaf extract was used to biosynthesize copper oxide nanoparticles (CuO-NPs). Various analytical techniques were used to characterize the produced CuO-NPs. Transmission electron microscope investigation indicated well-distributed spherical particles in various development phases. The particles’ diameters ranged from 22.15 to 37.01 nm, with an average of 24.8 ± 6.1 nm. Energy dispersive X-ray examination confirmed the presence of nanoscale Cu ions at a high concentration, as seen by the strong signal peak at 1 keV. Fourier transform infrared spectrum revealed various functional groups on the green-produced CuO-NPs, as evidenced by multiple absorption beaks. The bands found at 3,195 and 2,916 cm<jats:sup>−1</jats:sup> revealed that phenolic and flavonoid compounds’ alcohols and alkanes were stretching C–H. Also, a band at 1,034 cm<jats:sup>−1</jats:sup> is typically attributed to CuO production. CuO-NPs exhibited significant bioactivity against isolated and molecularly identified fungal strains, including <jats:italic>Rhizoctonia solani</jats:italic> (OR116528), <jats:italic>Fusarium oxysporum</jats:italic> (OR116508), and <jats:italic>Botrytis cinerea</jats:italic> (OR116491). Remarkably, the highest inhibition percentages were recorded at 100 µg/mL, with values 81.48, 71.11, and 50.74% for <jats:italic>R. solani</jats:italic>, <jats:italic>F. oxysporum</jats:italic>, and <jats:italic>B. cinerea</jats:italic>, respectively. Molecular docking interactions revealed that the highest binding affinity of CuO-NPs was −5.1 for the oxidoreductase of <jats:italic>B. cinerea</jats:italic> and −5.2 and −5.4 for the chitin synthase of <jats:italic>R. solani</jats:italic> and <jats:italic>F. oxysporum</jats:italic>, respectively. Consequentially, the biosynthesized CuO-NPs could be employed as antifungal biocontrol agents, as well as using <jats:italic>H. bacciferum</jats:italic> leaf extract for the synthesis of nanoparticles for various sustainable agricultural applications.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if1,9
dc.description.number1
dc.description.points70
dc.description.versionfinal_published
dc.description.volume22
dc.identifier.doi10.1515/chem-2024-0028
dc.identifier.issn2391-5420
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4218
dc.identifier.weblinkhttp://www.degruyter.com/document/doi/10.1515/chem-2024-0028/html
dc.languageen
dc.relation.ispartofOpen Chemistry
dc.relation.pagesart. 20240028
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.encopper oxide nanoparticles
dc.subject.enHeliotropium bacciferum
dc.subject.engreen synthesis
dc.subject.enantifungal activity
dc.subject.enplant disease
dc.subject.enmolecular docking
dc.titleCopper oxide nanoparticles-mediated <i>Heliotropium bacciferum</i> leaf extract: Antifungal activity and molecular docking assays against strawberry pathogens
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume22