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Expression Profiles of CDKN2A, MDM2, E2F2 and LTF Genes in Oral Squamous Cell Carcinoma

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cris.virtual.author-orcid0000-0002-1636-8278
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dc.abstract.enBackground: Oral squamous cell carcinoma (OSCC) is one of the most commonly detected neoplasms worldwide. Not all mechanisms associated with cell cycle disturbances are known in OSCC. Examples of genes involved in the control of the cell cycle are CDKN2A, MDM2, E2F2 and LTF. The aim of this study was to examine the possible association between CDKN2A, MDM2, E2F2 and LTF mRNA expression and influence on clinical variables. Methods: The study group consisted of 88 Polish patients. The gene expression levels were assessed by quantitative reverse transcription PCR. Results: We found no statistically significant differences in the expression level of CDKN2A, MDM2, E2F2 and LTF genes in tumour samples compared to margin samples. No association was found between the gene expression levels and clinical parameters, except E2F2. The patients with G2 tumours had a significantly higher gene expression level of E2F2 than patients with low-grade G1 tumours. Conclusions: We have not demonstrated that a change in expression profiles of genes has a significant impact on the pathogenesis of OSCC. It may also be useful to conduct further studies on the use of E2F2 expression profile changes as a factor to describe the invasiveness and dynamics of OSCC development.
dc.affiliationWydział Leśny i Technologii Drewna
dc.affiliation.instituteKatedra Urządzania Lasu
dc.contributor.authorGołąbek, Karolina
dc.contributor.authorRączka, Grzegorz
dc.contributor.authorGaździcka, Jadwiga
dc.contributor.authorMiśkiewicz-Orczyk, Katarzyna
dc.contributor.authorZięba, Natalia
dc.contributor.authorKrakowczyk, Łukasz
dc.contributor.authorMisiołek, Maciej
dc.contributor.authorStrzelczyk, Joanna Katarzyna
dc.date.access2026-01-30
dc.date.accessioned2026-02-10T10:04:16Z
dc.date.available2026-02-10T10:04:16Z
dc.date.copyright2022-11-23
dc.date.issued2022
dc.description.abstract<jats:p>Background: Oral squamous cell carcinoma (OSCC) is one of the most commonly detected neoplasms worldwide. Not all mechanisms associated with cell cycle disturbances are known in OSCC. Examples of genes involved in the control of the cell cycle are CDKN2A, MDM2, E2F2 and LTF. The aim of this study was to examine the possible association between CDKN2A, MDM2, E2F2 and LTF mRNA expression and influence on clinical variables. Methods: The study group consisted of 88 Polish patients. The gene expression levels were assessed by quantitative reverse transcription PCR. Results: We found no statistically significant differences in the expression level of CDKN2A, MDM2, E2F2 and LTF genes in tumour samples compared to margin samples. No association was found between the gene expression levels and clinical parameters, except E2F2. The patients with G2 tumours had a significantly higher gene expression level of E2F2 than patients with low-grade G1 tumours. Conclusions: We have not demonstrated that a change in expression profiles of genes has a significant impact on the pathogenesis of OSCC. It may also be useful to conduct further studies on the use of E2F2 expression profile changes as a factor to describe the invasiveness and dynamics of OSCC development.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,7
dc.description.number12
dc.description.points100
dc.description.versionfinal_published
dc.description.volume10
dc.identifier.doi10.3390/biomedicines10123011
dc.identifier.issn2227-9059
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7282
dc.identifier.weblinkhttps://www.mdpi.com/2227-9059/10/12/3011
dc.languageen
dc.relation.ispartofBiomedicines
dc.relation.pagesart. 3011
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enCDKN2A
dc.subject.enMDM2
dc.subject.enE2F2
dc.subject.enLTF
dc.subject.enoral squamous cell carcinoma
dc.subject.engene expression
dc.subject.encancer
dc.titleExpression Profiles of CDKN2A, MDM2, E2F2 and LTF Genes in Oral Squamous Cell Carcinoma
dc.title.volumeSpecial Issue State-of-the-Art Cancer Biology and Therapeutics in Poland
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue12
oaire.citation.volume10