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  4. Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition
 
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Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition

Type
Journal article
Language
English
Date issued
2024
Author
Studzińska-Sroka, Elżbieta
Paczkowska-Walendowska, Magdalena
Kledzik, Justyna
Galanty, Agnieszka
Gościniak, Anna
Szulc, Piotr 
Korybalska, Katarzyna
Cielecka-Piontek, Judyta
Faculty
Wydział Rolnictwa, Ogrodnictwa i Biotechnologii
Journal
Molecules
ISSN
1420-3049
DOI
10.3390/molecules29235775
Web address
https://www.mdpi.com/1420-3049/29/23/5775
Volume
29
Number
23
Pages from-to
art. 5775
Abstract (EN)
Black elderberry (Sambucus nigra L.) flowers are rich in polyphenolic compounds, including chlorogenic acid and quercetin derivatives, which are known for their health benefits, particularly their antioxidant and antidiabetic properties. This study aimed to optimize the extraction conditions using the Box–Behnken model to maximize polyphenol yields from different elderberry flower cultivars and to evaluate their potential for antidiabetic action. The extracts were analyzed for their phytochemical content and assessed for enzyme inhibition, specifically targeting enzymes critical in carbohydrate digestion and glucose regulation. The anti-inflammatory activity was also assessed. Results indicated that the Black Beauty, Obelisk, and Haschberg cultivars demonstrated significant inhibition of α-glucosidase, with a high inhibitory potential against α-amylase enzymes for the Obelisk cultivar. Additionally, high chlorogenic acid content was strongly correlated with enzyme inhibition and antioxidant activity, suggesting its substantial role in glucose regulation. This study underscores the potential of elderberry flower extracts, particularly those rich in chlorogenic acid, as natural agents for managing blood glucose levels, warranting further exploration of their use in antidiabetic applications.
Keywords (EN)
  • black elderberry

  • Sambucus nigra

  • wild elderberry

  • polyphenols

  • chlorogenic acid

  • antioxidant activity

  • α-glucosidase inhibition

  • α-amylase inhibition

  • extraction optimization

  • Box–Behnken model

License
cc-bycc-by CC-BY - Attribution
Open access date
December 6, 2024
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