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Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition

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cris.virtual.author-orcid0000-0002-9670-3231
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dc.abstract.enBlack elderberry (Sambucus nigra L.) flowers are rich in polyphenolic compounds, including chlorogenic acid and quercetin derivatives, which are known for their health benefits, particularly their antioxidant and antidiabetic properties. This study aimed to optimize the extraction conditions using the Box–Behnken model to maximize polyphenol yields from different elderberry flower cultivars and to evaluate their potential for antidiabetic action. The extracts were analyzed for their phytochemical content and assessed for enzyme inhibition, specifically targeting enzymes critical in carbohydrate digestion and glucose regulation. The anti-inflammatory activity was also assessed. Results indicated that the Black Beauty, Obelisk, and Haschberg cultivars demonstrated significant inhibition of α-glucosidase, with a high inhibitory potential against α-amylase enzymes for the Obelisk cultivar. Additionally, high chlorogenic acid content was strongly correlated with enzyme inhibition and antioxidant activity, suggesting its substantial role in glucose regulation. This study underscores the potential of elderberry flower extracts, particularly those rich in chlorogenic acid, as natural agents for managing blood glucose levels, warranting further exploration of their use in antidiabetic applications.
dc.affiliationWydział Rolnictwa, Ogrodnictwa i Biotechnologii
dc.affiliation.instituteKatedra Agronomii
dc.contributor.authorStudzińska-Sroka, Elżbieta
dc.contributor.authorPaczkowska-Walendowska, Magdalena
dc.contributor.authorKledzik, Justyna
dc.contributor.authorGalanty, Agnieszka
dc.contributor.authorGościniak, Anna
dc.contributor.authorSzulc, Piotr
dc.contributor.authorKorybalska, Katarzyna
dc.contributor.authorCielecka-Piontek, Judyta
dc.date.access2024-12-20
dc.date.accessioned2024-12-20T08:01:41Z
dc.date.available2024-12-20T08:01:41Z
dc.date.copyright2024-12-06
dc.date.issued2024
dc.description.abstract<jats:p>Black elderberry (Sambucus nigra L.) flowers are rich in polyphenolic compounds, including chlorogenic acid and quercetin derivatives, which are known for their health benefits, particularly their antioxidant and antidiabetic properties. This study aimed to optimize the extraction conditions using the Box–Behnken model to maximize polyphenol yields from different elderberry flower cultivars and to evaluate their potential for antidiabetic action. The extracts were analyzed for their phytochemical content and assessed for enzyme inhibition, specifically targeting enzymes critical in carbohydrate digestion and glucose regulation. The anti-inflammatory activity was also assessed. Results indicated that the Black Beauty, Obelisk, and Haschberg cultivars demonstrated significant inhibition of α-glucosidase, with a high inhibitory potential against α-amylase enzymes for the Obelisk cultivar. Additionally, high chlorogenic acid content was strongly correlated with enzyme inhibition and antioxidant activity, suggesting its substantial role in glucose regulation. This study underscores the potential of elderberry flower extracts, particularly those rich in chlorogenic acid, as natural agents for managing blood glucose levels, warranting further exploration of their use in antidiabetic applications.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,2
dc.description.number23
dc.description.points140
dc.description.reviewreview
dc.description.versionfinal_published
dc.description.volume29
dc.identifier.doi10.3390/molecules29235775
dc.identifier.issn1420-3049
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/2259
dc.identifier.weblinkhttps://www.mdpi.com/1420-3049/29/23/5775
dc.languageen
dc.relation.ispartofMolecules
dc.relation.pagesart. 5775
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enblack elderberry
dc.subject.enSambucus nigra
dc.subject.enwild elderberry
dc.subject.enpolyphenols
dc.subject.enchlorogenic acid
dc.subject.enantioxidant activity
dc.subject.enα-glucosidase inhibition
dc.subject.enα-amylase inhibition
dc.subject.enextraction optimization
dc.subject.enBox–Behnken model
dc.titleAntidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue23
oaire.citation.volume29