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Efficacy of zinc nanoparticle supplementation on ruminal environment in lambs

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dc.abstract.enBackground: Zinc nanoparticles (NPs) are characterized by high bioavailability, small size, and high absorbability. The purpose of this experiment was to determine the effect of Zn-NP feed supplementation on ruminal fermentation, microbiota, and histopathology in lambs. In vitro (24 h), short-term (STE, 28 d), and long-term (LTE, 70 d) experiments were performed. The lambs in STE were fed a basal diet (BD) composed of 350 g/d ground barley and 700 g/d meadow hay (Control), BD enriched with ZnO-NPs (80 mg Zn/kg of diet, ZnO-NPs), and BD enriched with Zn phosphate-based NPs (80 mg Zn/kg of diet, ZnP-NP). The in vitro gas production technique was used in incubated rumen fluid from STE. The lambs in LTE were fed BD (Control), BD enriched with ZnO-NPs (40 mg Zn/kg of diet, ZnONP40), BD enriched with ZnO-NPs (80 mg Zn/kg of diet, ZnO-NP80) and BD enriched with ZnO (80 mg Zn/kg of diet, ZnO-80). Results: After 24 h of incubation, dry matter digestibility was higher for ZnO-NP and ZnP-NP substrates than the control in an in vitro experiment (P < 0.001). The total bacterial population in the STE was lower (P < 0.001) in the ZnP-NP group than in the control and ZnO-NP groups, but the protozoan populations were not significantly different. The ammonia-N concentration in LTE was lowest in the ZnO-NP80 group (P = 0.002), but the activities of carboxymethyl cellulase (P < 0.001) and xylanase (P = 0.002) were higher in the ZnO-NP40, ZnO-NP80, and ZnO-80 groups than in the control group. Morphological observation after STE and LTE revealed histological changes (e.g. inflammation of the epithelium or edema of the connective tissue) in the rumen of lambs. Conclusion: Zn-NP supplementation up to 70 d improved feed-use efficiency and influenced ammonia-N concentration and activities of hydrolases in the rumen. The active ruminal fermentation affected the health of the ruminal papillae and epithelium in the lambs, regardless of the application’s form, dose, or duration. However, by affecting rumen microbial fermentation, Zn-NPs could alter fermentation patterns, thereby increasing the capacity of host rumen epithelial cells to transport short-chain fatty acids.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Nauk Przedklinicznych i Chorób Zakaźnych
dc.affiliation.instituteKatedra Genetyki i Podstaw Hodowli Zwierząt​​
dc.affiliation.instituteKatedra Żywienia Zwierząt
dc.contributor.authorPetrič, Daniel
dc.contributor.authorMikulová, Klára
dc.contributor.authorBombárová, Alexandra
dc.contributor.authorBatťányi, Dominika
dc.contributor.authorČobanová, Klaudia
dc.contributor.authorKopel, Pavel
dc.contributor.authorŁukomska, Anna
dc.contributor.authorPawlak, Piotr
dc.contributor.authorSidoruk, Pola
dc.contributor.authorKotwica, Szymon
dc.contributor.authorCieślak, Adam
dc.contributor.authorVáradyová, Zora
dc.date.access2025-01-13
dc.date.accessioned2025-01-13T09:01:46Z
dc.date.available2025-01-13T09:01:46Z
dc.date.copyright2024-09-21
dc.date.issued2024
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if2,3
dc.description.points140
dc.description.reviewreview
dc.description.versionfinal_published
dc.description.volume20
dc.identifier.doi10.1186/s12917-024-04281-8
dc.identifier.issn1746-6148
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/2324
dc.identifier.weblinkhttps://link.springer.com/article/10.1186/s12917-024-04281-8
dc.languageen
dc.pbn.affiliationanimal science and fisheries
dc.relation.ispartofBMC Veterinary Research
dc.relation.pagesart. 425
dc.rightsCC-BY-NC-ND
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enRuminal microorganisms
dc.subject.enZinc nanoparticles
dc.subject.enFermentation
dc.subject.enRuminal histology
dc.titleEfficacy of zinc nanoparticle supplementation on ruminal environment in lambs
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume20