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Lower plasma glutathione, choline, and betaine concentrations are associated with fatty liver in postmenopausal women

cris.virtual.author-orcid0000-0002-1494-397X
cris.virtual.author-orcid0000-0003-4570-7221
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid0000-0002-2045-0709
cris.virtualsource.author-orcid6f997090-2297-4f0d-b28f-f3a6f14e3c19
cris.virtualsource.author-orciddafe00c4-99bb-45f5-8886-d6f261ff6cb3
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid20ac3fe1-f398-4ef7-ab0b-a6a20460f69f
dc.abstract.enPostmenopausal women are at high risk of hepatic steatosis, which may be associated one-carbon metabolism (OCM) abnormalities. We hypothesized that lower folate, choline, betaine, and glutathione (GSH) concentrations but higher total homocysteine and trimethylamine N-oxide concentrations are associated with fatty liver (FL) in postmenopausal women. We aimed to identify relationships between OCM and nonalcoholic fatty liver disease biomarkers in postmenopausal women. A total of 131 postmenopausal women participated in this study and were stratified by the incidence of FL based on the hepatic steatosis index (HSI). Food intake was evaluated using dietary records. Aspartate aminotransferase and alanine aminotransferase concentrations in serum were measured using the colorimetric method. Total homocysteine and GSH concentrations in plasma were measured using high-performance liquid chromatography. Folate and phosphatidylcholine (PC) concentrations were determined in red blood cells using an enzyme-linked immunosorbent assay. Other OCM biomarkers concentrations were measured using the isotope dilution analysis. Women with FL (HSI > 36) had lower GSH, choline, and betaine concentrations than women without FL (HSI < 36). Higher HSI level was negatively correlated with betaine and PC and positively correlated with plasma choline/betaine ratio. Lower GSH and higher carnitine concentrations in the blood are associated with an increased risk of FL. MTHFR (rs180130) T-allele carriers had lower levels of GSH than the CC homozygotes. Postmenopausal women with FL have lower GSH, choline, and betaine concentrations, which may play a role in fat accumulation in the liver. It seems important to consider the dietary intakes of these nutrients in postmenopausal women.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.affiliation.instituteKatedra Technologii Żywności Pochodzenia Roślinnego
dc.contributor.authorMuzsik-Kazimierska, Agata Joanna
dc.contributor.authorSzwengiel, Artur
dc.contributor.authorNikrandt, Grzegorz
dc.contributor.authorChmurzyńska, Agata
dc.date.accessioned2026-03-24T08:12:12Z
dc.date.available2026-03-24T08:12:12Z
dc.date.issued2022
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,5
dc.description.numberMay 2022
dc.description.points70
dc.description.volume101
dc.identifier.doi10.1016/j.nutres.2022.02.004
dc.identifier.eissn1879-0739
dc.identifier.issn0271-5317
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7896
dc.languageen
dc.relation.ispartofNutrition Research
dc.relation.pages23-30
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enone-carbon metabolism
dc.subject.enfatty liver
dc.subject.enhepatic steatosis index
dc.subject.enMTHFR gene
dc.subject.enPEMT gene
dc.subject.enpostmenopausal women
dc.titleLower plasma glutathione, choline, and betaine concentrations are associated with fatty liver in postmenopausal women
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume101