Cornelian cherry fruits as a source of compounds that protect proteins from oxidative stress

Introduction: Cornelian cherry (Cornus mas L.) fruits are rich in vitamin C, phenolics and other compounds shaping their high antioxidant profile. Natural-based antioxidants may inhibit degradation of pivotal biological macromolecules such as DNA, proteins and molecular membranes.
Objective: The study aimed to assess the cornelian cherry extract effect on the inhibition of protein oxidation, which could help limit generation of the advanced oxidation protein products (AOPPs), that are responsible for inflammatory states.
Methods: The protective effect was evaluated in in vitro model, in which albumin solution was exposed to oxidation stress in the presence of different doses of C. mas extract. The results were supported by characteristics of the extract under their total phenolic, total flavonoid and vitamin C content. Also, the antioxidant potential was validated using ABTS test (TEAC).
Results: Observed was moderate inhibitory effect of the extract and antiradical activity against ABTS. However, both studied effects rather result from other bioactive compounds than the flavonoids.
Conclusion: Cornelian cherry fruits has moderate potential to inhibit protein oxidation. However, the observed antioxidant effect rather depends on other compounds than the flavonoids and vitamin C. Nonetheless, the collected results could be helpful in future designing and development of plant-based agents inhibiting the formation of AOPPs.