Simple item page
 

Influence of supplementation of probiotic bacteria Lactobacillus plantarum and Lactobacillus curvatus on selected parameters of liver iron metabolism in rats on high-fat iron-deficient diet

cris.virtual.author-orcid0000-0002-4173-5965
cris.virtual.author-orcid0000-0002-5418-5632
cris.virtual.author-orcid0000-0002-4731-6243
cris.virtual.author-orcid0000-0001-8417-2245
cris.virtual.author-orcid0000-0002-0937-8427
cris.virtualsource.author-orcidc8f75a2c-3403-4f93-aa73-6cf0ae8b543d
cris.virtualsource.author-orcidccd52a90-8355-4384-b6ea-c94578ebf2ce
cris.virtualsource.author-orcidd951fe7e-3886-48a5-8661-b05d0c844622
cris.virtualsource.author-orcidedf63522-bb89-4788-a8d3-9c3f3858875b
cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
dc.abstract.enBackground Iron deficiency constitutes the most frequent diet deficit. A high-fat diet also leads to disturbances in iron metabolism. There is evidence that probiotics favorably influence iron turnover. Purpose To compare the influence of supplementation with probiotic Lactobacillus plantarum and Lactobacillus curvatus with and without iron supply on liver iron metabolism in rats on high-fat iron-deficient diet. Methods In the first stage (8 weeks), rats were fed a control diet (group C, n = 8), high-fat diet (group HF, n = 8), or high-fat iron-deficient diet (group HFDEF, n = 48). In the second stage (8 weeks), the rats in the C and HF groups were kept on the same diets, while the rats in the HFDEF group were divided into 6 groups (n = 8 each) and fed as follows: group HFDEF- high-fat iron-deficient diet, group HFDEFFe- high-fat iron-deficient diet with iron supplementation, groups HFDEFLp and HFDEFLc- high-fat iron-deficient diet with L. plantarum or L. curvatus supplementation, respectively, and groups HFDEFFeLp and HFDEFFeLc- high-fat iron-deficient diet supplemented with iron and L. plantarum or L. curvatus, respectively. The rats were subsequently sacrificed, and their serum and liver samples were collected for analysis. Results Serum ferroportin level was higher in the HFDEFFe, HFDEFLp, HFDEFLc, and HFDEFFeLp groups than in the C and HFDEF groups. The hepatic expression of type 1 transferrin receptor gene (Tfrc) was higher in the HFDEFFeLc group than in the C group. No differences in serum iron, hepcidin, hemojuvelin, transferrin, and ferritin levels and in hepatic type 2 transferrin receptor gene expression were observed between the groups. Conclusions In rats on high-fat iron-deficient diet, the supplementation of L. curvatus and L. plantarum increased serum ferroportin concentration, and L. curvatus enhanced liver expression of the Tfrc gene.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.contributor.authorSkrypnik, Katarzyna
dc.contributor.authorOlejnik-Schmidt, Agnieszka
dc.contributor.authorMikołajczyk-Stecyna, Joanna
dc.contributor.authorSchmidt, Marcin
dc.contributor.authorSuliburska, Joanna
dc.date.access2026-02-04
dc.date.accessioned2026-02-04T13:40:44Z
dc.date.available2026-02-04T13:40:44Z
dc.date.copyright2022-08-11
dc.date.issued2022
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if5,6
dc.description.numberSeptember 2022
dc.description.points100
dc.description.versionfinal_published
dc.description.volume96
dc.identifier.doi10.1016/j.jff.2022.105205
dc.identifier.eissn2214-9414
dc.identifier.issn1756-4646
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7149
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S1756464622002754
dc.languageen
dc.relation.ispartofJournal of Functional Foods
dc.relation.pagesart. 105205
dc.relation.projectBadanie wpływu Lactobacillus plantarum ATCC14917 na gospodarkę żelaza u szczurów na diecie wysokotłuszczowej
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enprobiotics
dc.subject.eniron
dc.subject.enminerals
dc.subject.eniron deficiency
dc.subject.enhemojuvelin
dc.subject.engene expression
dc.titleInfluence of supplementation of probiotic bacteria Lactobacillus plantarum and Lactobacillus curvatus on selected parameters of liver iron metabolism in rats on high-fat iron-deficient diet
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume96