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Exploring glycosylated soy isoflavones affinities toward G-tetrads as studied by survival yield method

cris.lastimport.scopus2025-10-23T06:58:29Z
cris.virtual.author-orcid0000-0003-1305-6866
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcidf8bfe92f-a0be-4da9-9adc-d01fadc9c9d7
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enTaking soy-based food supplements for menopausal symptomsby women may reduce the risk of cancer. Therefore, theinteraction between nucleic acids (or their constituents) andingredients of the supplements, e. g., isoflavone glucosides, onthe molecular level, has been of interest with respect to cancertherapy. In this work, the interaction between isoflavoneglucosides and G-tetrads, namely [4G + Na]+ ions (G stands forguanosine or deoxyguanosine), were analyzed by using electro-spray ionization-collision induced dissociation-mass spectrome-try (ESI-CID-MS) and survival yields method. The strength ofisoflavone glucosides-[4G + Na]+ interaction in the gas phasewas determined from Ecom50 – the energy required to fragment50 % of selected precursor ions. Glycitin-[4G + Na]+ interactionwas found to be the strongest, and the interaction betweenisoflavone glucosides and guanosine tetrad was established tobe stronger than that between isoflavone glucosides anddeoxyguanosine tetrad.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Biochemii i Analizy Żywności
dc.contributor.authorStężycka, Olga
dc.contributor.authorFrańska, Magdalena
dc.contributor.authorBeszterda-Buszczak, Monika
dc.date.accessioned2025-09-18T12:51:30Z
dc.date.available2025-09-18T12:51:30Z
dc.date.issued2023
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if2,3
dc.description.number10
dc.description.points100
dc.description.volume24
dc.identifier.doi10.1002/cphc.202300056
dc.identifier.eissn1439-7641
dc.identifier.issn1439-4235
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4929
dc.languageen
dc.relation.ispartofChemPhysChem
dc.relation.pagese202300056
dc.rightsClosedAccess
dc.sciencecloudsend
dc.titleExploring glycosylated soy isoflavones affinities toward G-tetrads as studied by survival yield method
dc.typeJournalArticle
dspace.entity.typePublication